ABSTRACT
We have studied the distribution of the new compound 4-methyl-2,6-diisobornylphenol in rats after a single oral administration in a dose of 20 mg/kg. The pharmacokinetic parameters have been estimated by the noncompartmental method. It is established that the drug is nonuniformly distributed in the body and has a high affinity for liver and heart. A low penetration of 4-methyl-2,6-diisobornilphenol has been found in brain tissue. The accumulation of 4-methyl-2,6-diisobornilphenol in adipose tissues has not been found. It been showed that the drug is slowly eliminated from the body, especially from the heart tissues for which the mean retention time is MRT = 45 h.
Subject(s)
Camphanes/pharmacokinetics , Cresols/pharmacokinetics , Fibrinolytic Agents/pharmacokinetics , Adipose Tissue/metabolism , Administration, Oral , Animals , Brain/metabolism , Camphanes/blood , Cresols/blood , Female , Fibrinolytic Agents/blood , Kidney/metabolism , Liver/metabolism , Male , Muscles/metabolism , Myocardium/metabolism , Rats , Rats, Wistar , Tissue DistributionABSTRACT
The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.
Subject(s)
Antioxidants/pharmacokinetics , Camphanes/pharmacokinetics , Cresols/pharmacokinetics , Intestinal Mucosa/metabolism , Animals , Antioxidants/administration & dosage , Antioxidants/metabolism , Area Under Curve , Camphanes/administration & dosage , Camphanes/blood , Cresols/administration & dosage , Cresols/blood , Drug Administration Schedule , Intestinal Absorption/physiology , Male , Rats , Rats, Wistar , StomachABSTRACT
The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).
