[Correction of immunologic disorders in patients with chronic suppurative otitis media]. / Korrektsiia immunologicheskikh narushenii u bolnykh khronicheskim gnoinym srednim otitom.

The absolute and relative content of T- and B-lymphocytes, T-helpers (CD4), T-suppressors (CD8), phagocytosis, complement and immunoglobulins A, M, G in the blood serum was examined in patients with chronic purulent otitis media. The investigation also involved tests on immunological activity of tymoptin (T), sodium nucleinate (SN), prodigiosan (PR), the combination of SN with PR. 148 patients aged 15-56 years were subdivided into 5 groups. In pretreatment immunological status of all the patients the count of T- and B-lymphocytes, T-helpers, phagocytosis were reduced against increased counts of IgM and T-suppressora. All the patients received similar conventional treatment with adjuvant SN (group 2), PR (group III), SN + PR (group 4), T (group 5). The conventional conservative and especially surgical treatment aggravated immunodeficiency. The adjuvant immunocorrectors potentiated the treatment effects which appeared to be most beneficial in group V followed by by groups IV, II and III in diminishing order.

[Some immunologic indices in patients with chronic polypous rhinosinusitis]. / Nekotorye immunologicheskie pokazateli u bolnykh khronicheskim polipoznym rinosinusitom.

Such immunological indices as the number of T- and B-cells in a rosette-formation test, T-cell sensitivity to theophylline, quantity of the main Ig classes and CIC were investigated in 43 patients with primary chronic polypous rhinosinusitis and 34 patients with recurrent polypous rhinosinusitis. Elevated levels were registered of IgG, IgM, IgA and CIC this evidencing hyperfunction of B-cell immunity. Immunocorrection with sodium nucleinate in surgical treatment of sinusitides contributed to more rapid recovery of the patients.

[Retrospective analysis of diagnostic and therapeutic results in patients with inflammatory diseases of the frontal sinus]. / Retrospektivnyi analiz rezul'tatov diagnostiki i lechenia bol'nykh s vospalitel'nymi zabolevaniiami lobnykh pazukh.

The diagnosis, clinical course and therapy of inflammatory diseases of frontal sinuses of 213 patients, aged 14 to 80 years, were investigated. In 104 patients the process was acute and in 109 patients it was chronic. 63% of patients suffered from purulent, 15% of them--from catarrhal, and 21.6% of them--from purulent-polypous frontal sinusitis 89.2% of patients showed unilateral and 10.8% of them bilateral lesions; 47.4% of patients displayed combined lesions of paranasal sinuses. For diagnostic and therapeutic purposesal 23.5% of patients were exposed to sinusal catheterization and irrigation according to the method of E.A. Landsberg; 7.5% of patients--to trepanopuncture, and 50.7% of patients--to frontotomy. 48.1% of operated patients developed relapses. After conservative treatment, which included catheterization and irrigation of frontal sinuses, relapses were seen only in 2.1% of patients. Our analysis demonstrated advantages of endonasal catherization of frontal sinuses in the diagnosis and therapy of frontal sinusitis and gave evidence that the manipulation was possible and safe in essentially all the patients treated.

[Treatment of secretory otitis media]. / Lechenie sekretornykh srednikh otitov.

Blood serum of 38 patients with otitis media (14 men and 24 women), aged 16 to 55 years, was examined immunologically. The patients were subdivided into two groups that received identical traditional therapy. However the Group 2 patients were also given per os 0.5 g sodium nucleinate 3 times a day for 10 days. Before and after treatment all the patients underwent immunological tests which included measurements of T- and B-lymphocytes, T-helpers and T-suppressors as well as immunoglobulins M, A, G and complement. It was demonstrated that sodium nucleinate exerted beneficial clinical and immunological effects.