[The possibilities of application of iodinedicerinum in urgent surgery]. / Vozmozhnosti ispol'zovaniia iodditserina v neotlozhnoi khirurgii.

Application of ioddicerynum while performance of an urgent operative intervention in 63 patients with an acute appendicitis, perforated gastroduodenal ulcer and an old postoperative abscess of anterior abdominal wall had permitted to lower the occurrence frequency for postoperative purulent complications by two times.

[Neurophysiological mechanisms of the action of GABA-tropic agents on brain structures]. / Neirofiziologicheskie mekhanizmy deistviia GAMK-tropnykh sredstv na struktury golovnogo mozga.

The effect of systemic administration of agonists and antagonists of GABA system on excitability and intracentral relationships of the brain structures was found during chronic experiments on rabbits with bipolar electrodes implanted in the region of the frontal cortex, dorsal hippocampus, midbrain reticular formation and central gray matter. The changes of the functional state of the cerebral formations were suggested to be related to a different degree of the involvement of GABA receptors of types A and B.

[Comparative characteristics of the functioning of brain structures exposed to morphine and D-phenylalanine]. / Sravnitel'naia kharakteristika funktsionirovaniia struktur mozga pri deistvii morfina i D-fenilalanina.

In experiments on rats it was shown that morphine and D-phenylalanine in doses of 5 and 100 mg/kg, respectively, produce a similar by the degree increase of pain reaction thresholds at stimulation of paws through the electrified floor of the chamber. Experiments on rabbits demonstrated that the main factor in morphine action is a decrease of excitability and blood filling of the reticular formation of the midbrain and the central gray matter and an increase of excitability of the dorsal hippocamp without significant changes in the frontal cortex excitability. D-phenylalanine also caused a decrease of excitability of the reticular formation but in contrast to morphine failed to change excitability of the dorsal hippocamp and enhanced excitability of the central gray matter.

[Characteristics of memory and the functional organization of the hippocampo-reticulo-neocortical complex of the brain in the acute postoperative period]. / Kharakteristika pamiati i funktsional'noi organizatsii gippokampo-retikulo-neokortikal'nogo kompleksa mozga v ostrom posleoperatsionnom periode.

In tests on dogs, rabbits and rats, it has been established that in acute postoperative period, the time of memorizing of conditioned signals (light, tone and metronome) is reduced, the time of realization of conditioned reactions increases, the excitability and the bloodflow of the midbrain reticular formation and Mg-AtPhase activity of pons Varolii raise. In the hippocampus the excitability and local bloodflow lower and the activity of Ca-Mg-ATPhase is enhanced. In the frontal cortex these processes do not change. Functional interrelations of the brain structures in the acute postoperative period are characterized by the weakening of the activating influence of the reticular formation on the frontal cortex and an increase of its suppressive action on the dorsal hippocampus. It is suggested, that the discovered damages in the higher nervous activity are stipulated by the changes in neurochemical organization of the brain.

[Changes in the reactive properties of the body under anesthesia against a background of aspartic acid premedication]. / Izmenenie reaktivnykh svoistv organizma v usloviiakh narkoza na fone premedikatsii asparaginovoi kislotoi.

It was shown in acute experiments on mice and dogs that aspartic acid and its sodium salt administered 15-30 minutes prior to ether and hexenal anesthesia prolong the animals' life span by 42.2-99.9% compared to control given an isotonic solution of sodium chloride. The stabilizing action of the aspartate is accounted for by its effect on the reactive properties of the central nervous system, particularly on the new cortex, old cortex, archicortex and circulation. This effect is also associated with the increased oxygen tension in brain tissues, with increased heart contractions and slowing down of their rhythm.

[Comparative intensity of oxidative phosphorylation in different regions of the cerebral cortex of intact animals during anesthesia and hypoxia]. / Sravnitel'naia intensivnost' okislitel'nogo fosforilirovaniia v razlichnykh otdelakh kory golovnogo mozga intaktnykh zhivotnykh v usloviiakh narkoza i gipoksii.

Experiments on 54 dogs with the use of the manometric method of Warburg proved that the level of oxidative phosphorylation in the brain cortex segments differing in the level of their phylogenic development is dissimilar. In the new cortex segment (sensomotor region) the oxygen and inorganic phosphorus uptake as well as the degree of their conjugation, as compared to the energy exchange intensity in the tissues of the old cortex (hippocampus), were found to show a higher level. Anesthetics, such as ether and sodium hexobarbital caused dissociation of the oxidative phosphorylation, more pronounced in the elements of the old cortical segments than in the new ones. The suppression of biochemical processes was especially profound under the effect of sodium hexobarbital and less marked under an ether poisoning. Hypoxia and combined action of an anesthetic and hypoxia produced inhibition of the energy exchange, more intensive in the new cortical segments.

[Comparative reactivity of the neo-, paleo- and archicortex of the brain under conditions of ether and hexanal anesthesia]. / Sravnitel'naia reaktivnost' novoi, staroi i drevnei kory golovnogo mozga v usloviiakh éfirnogo i geksenalovogo narkoza

In acute experiments on dogs subject to investigation under ether- and hexobarbital sodium-induced anesthesia was comparative reactivity of the neo-(sensomotor region), paleo-(hippocampus) and archicortex (olfactory lobe) of the brain. It was found that following administration of low and medium doses of general anesthetics more marked EEG changes, with but an insignificant inhibition of respirations and a slight fall in arterial pressure, were observed to occur in the hippocampus and in the olfactory lobe, as against the biocurrents in the sensomotor region. Such a regularity continued for as long as the oxygen tension in the neocortex was maintained at a level higher than in the paleo-and archicortex. Upon introduction of toxic ether and hexobarbital doses the oxygen tension in the neocortex dropped earlier and the inhibition of its bioelectric activity would set in concurrently or sooner than in the olfactory lobe and in the hippocampus.