ABSTRACT
The role of the kinin system (KS) in pathogenesis of endotoxin shock was investigated. In the lymph and blood flowing out of the small intestine and in the liver the activity of KS was measured 30, 60, 90 and 120 min after injection of the sublethel dose of endotoxin E coli 0 111 B4. The results suggest that in the lymph and blood flowing from the intestine KS activity occurs during the first minutes of endotoxin shock. In the liver KS activity was observed during the second hour of shock development followed by enhancing synthesis of KS components in the presence of KS higher activity and kinin developing function exhaustion to the end of the third hour of shock duration.
Subject(s)
Intestinal Mucosa/metabolism , Kinins/metabolism , Liver/metabolism , Lymph/metabolism , Shock, Septic/metabolism , Animals , Dogs , Female , Kinins/blood , Male , Shock, Septic/bloodSubject(s)
L-Lactate Dehydrogenase/metabolism , Lymph/enzymology , Animals , Dogs , Extremities , Lymph/physiologySubject(s)
Blood Coagulation , Lymph/physiology , Periapical Periodontitis/blood , Animals , Blood Coagulation Tests , Dogs , Female , Male , Time FactorsABSTRACT
The experiments on 25 dogs have shown a considerable decrease in the consumption of clotting factors and reduced hyperfibrinolysis with the onset of disseminated intravascular coagulation syndrome in animals poisoned with acetic essence (2 ml/kg).
Subject(s)
Disseminated Intravascular Coagulation/therapy , Drainage , Lymph/physiology , Thoracic Duct , Acetates/poisoning , Acetic Acid , Animals , Blood Coagulation Tests , Disseminated Intravascular Coagulation/blood , Disseminated Intravascular Coagulation/etiology , Dogs , Female , MaleSubject(s)
Blood Coagulation , Lymph/physiology , Lymphatic System/physiology , Thoracic Duct/physiology , Animals , Blood Coagulation Tests , Dogs , Female , Fibrinolysis , MaleABSTRACT
The mechanism of radioactive heparin S-35 transport in the connective tissue of hindlimbs, was studied in dogs. The transport was shown to occur only via lymphatic capillaries if the lympho-blood flow is present in prenodal lymphatic ducts of popliteal lymphatic nodes and v. saphena. The radioactive heparin appears in the blood in 20 min after its registration in lymph.