[Prospects for using combined three-dimensional injection of gel transplants with autologous and allogenic cell cultures in reproductive medicine].

A combined cellular transplant for injection has been designed, by using lowly differentiated stromal fat tissue cells obtained from Wistar rats and it preserved biological and physical properties after passing through a small-diameter injection needle (an insulin syringe). A morphological study of the results of its transplantation into paraurethral tissues in 28 female rats showed that the transplant cells, autologous ones in particular, activated the proliferation of local connective tissue cell populations and retained their viability and proliferative and synthetic activities up 20 days or more. At the end of the experiment (on days 27-35), marked focal connective tissue enlargement at the site of injection of both allo- and autografts results in the narrowing of the urethral lumen. The injection implantation of combined allo- and autografts opens up new avenues for the treatment of pathological processes of the reproductive and urinary tracts.

[Antihormones and laparoscopy in the combined treatment of disseminated forms of genital endometriosis externa]. / Antigormony i laparoskopiia v kombinirovannom lechenii rasprostranennykh form naruzhnogo genital'nogo éndometrioza.

A total of 100 patients with disseminated forms of external genital endometriosis were administered multiple-modality treatment including surgery and antihormone therapy. Twenty patients with the same diagnosis were controls and subjected to surgery alone. The results of treatment assessed on the basis of analysis of the clinical course of the disease, status of the menstrual and generative functions, drug effects on the central nervous system, hormonal status, and target organs (mammary glands and osseous tissue) evidence good potentialities of laparoscopy and high efficacy of subsequent therapy with antihormones in the treatment of patients with grave forms of endometriosis.