ABSTRACT
In Uzbekistan and Moldova 542 children born of HBsAg carriers were immunized against hepatitis B (with vaccine Engerix B according to the immunization schedule of 4 injections). Anti-HBs antibodies in protective titers were detected by EIA and RIA techniques in 76.7% of children aged 4-5 months after the 3rd injection, in 95.7% of children aged 15-16 months and in 90.0% of children aged 2-2.5 years after the 4th (booster) injection. In the control group (117 nonimmunized children born of HBs carriers) observed during the same period anti-HBs antibodies were detected significantly less frequently (in 7.3%, 11.6% and 12.9% of these children respectively). 1-2 months after the course of immunization was completed 74.1% of the immunized children had high anti-HBs antibody titers (exceeding 1000 IU/ml) with their subsequent decrease by 2-2.5 years of age. In the control group these figures were 27.1% and 29.0% respectively. The index of immunization effectiveness obtained by the comparison of the hepatitis B morbidity rates in both groups was 7.8. No postvaccinal complications were registered.
Subject(s)
Carrier State/immunology , Hepatitis B Surface Antigens/blood , Hepatitis B Vaccines/immunology , Hepatitis B/immunology , Hepatitis B/prevention & control , Vaccines, Synthetic/immunology , Analysis of Variance , Drug Evaluation , Female , Hepatitis B Antibodies/blood , Hepatitis B Vaccines/adverse effects , Hepatitis B e Antigens/blood , Humans , Infant , Infant, Newborn , Male , Moldova , Pregnancy , Uzbekistan , Vaccines, Synthetic/adverse effectsABSTRACT
The efficacy of elimination of enteric viruses from water in the process of exploitation of a closed irrigating system is evaluated. Experimental and natural observations showed the half-life of the index virus in the water objects of the irrigating system to be 1.57 days. The potentials of using a temperature-dependent variant of poliomyelitis virus as the internal control in studies of the prevalence of enteric virules among human subjects and in the environment under conditions of intensive irrigated agriculture are considered.
Subject(s)
Agriculture , Enterovirus/isolation & purification , Sanitation , Water Microbiology , Enterobacteriaceae/isolation & purification , Fresh Water , Hydrogen-Ion Concentration , Moldova , Poliovirus/isolation & purification , Temperature , Virus Cultivation/methodsABSTRACT
The share of various etiologic forms of acute intestinal infections, diagnosed by bacteriologic methods, is presented. The share of gastroenterocolitis induced by opportunistic microflora makes up 35.6%, that of dysentery 25.6%, salmonellosis 18.5%; mixed infection (dysentery + salmonellosis) is diagnosed in 7% of cases with acute intestinal infections. The principal representative of opportunistic microflora isolated from patients with acute intestinal infections is the Klebsiella genus (40.6%), whereas in the reference group Citrobacter, Morganella, and Klebsiella detection rates are approximately the same (27.0-18.3%). Opportunistic microorganisms in titers under 10(6) are isolated from normal subjects 5 times more frequently than from the patients, this indicating the diagnostic value of this level of feces contamination with opportunistic microflora.
Subject(s)
Dysentery, Bacillary/diagnosis , Intestinal Diseases/etiology , Opportunistic Infections/etiology , Salmonella Infections/diagnosis , Acute Disease , HumansABSTRACT
A possibility of construction of a mathematical model for current prognosing of aseptic meningitis incidence both for 2-4 months in advance and for the whole year has been demonstrated. The initial information consisted of the data on prevalence of enteroviruses in water objects as from May. Comparison of the actual and estimated incidence indicates that with the proposed model, up to 90.4% of the incidence of aseptic meningitis may be explained.
Subject(s)
Computer Simulation , Enterovirus Infections/epidemiology , Meningitis, Aseptic/epidemiology , Meningitis, Viral/epidemiology , Meningitis/epidemiology , Water Microbiology , Enterovirus Infections/etiology , Humans , Incidence , Meningitis, Aseptic/etiology , Meningitis, Viral/etiology , Prognosis , Regression Analysis , Time FactorsABSTRACT
The guanidine-dependent variant of poliovirus type I was shown to survive in soil and on tomato plants for 60 and 25 days, and in the roots, stems, leaves for 15, 20, and 8 days, respectively. Extrapolation of the significance of these results indicates that the decline of concentration of the indicator virus in the soil and on the vegetables and its increase and decline in the root system, stems, leaves, and in tomatoes is of exponential nature.
