ABSTRACT
INTRODUCTION: Anti-Hu and anti-Yo are the most well-known anti-neuronal antibodies. The anti-Ri antibodies, which are less common, are generally found in subjects with opsoclonus-myoclonus, often associated with breast cancer. CASE REPORT: A 54-year-old woman presented anti-Ri antibodies associated with a paraneoplastic syndrome and unusual symptoms of ophthalmoplegia, blepharospasm, palilalia and ataxia. Adenocarcinoma of the breast was also found. After chemotherapy, radiotherapy, and several immunoglobulin infusions, the patient did not improve ten months after tumor surgery. CONCLUSION: Anti-Ri antibodies associated with paraneoplastic syndrome can be observed in patients who develop a rapidly progressive brainstem tumor. Breast or lung cancer and conduct to search a breast or pulmonary cancer.
Subject(s)
Autoantibodies/immunology , Blepharospasm/etiology , Ophthalmoplegia/etiology , Paraneoplastic Syndromes, Nervous System/complications , Speech Disorders/etiology , Adenocarcinoma/complications , Adenocarcinoma/drug therapy , Adenocarcinoma/therapy , Antineoplastic Agents/therapeutic use , Blepharospasm/immunology , Breast Neoplasms/complications , Breast Neoplasms/drug therapy , Breast Neoplasms/therapy , Female , Humans , Immunization, Passive , Middle Aged , Ophthalmoplegia/immunology , Paraneoplastic Syndromes, Nervous System/immunologySubject(s)
Diplopia/etiology , Polychondritis, Relapsing/complications , Aged , Humans , Male , Recurrence , Uveitis/etiologyABSTRACT
We report one case of acute cervical spinal cord infarction characterized by motor impairment of the upper limbs with respect of the lower limbs. It occurs infrequently. The purpose of this paper is to discuss the clinical, neurophysiological and magnetic resonance imaging findings, and to review the presumed mechanisms of spinal cord infarction.
