ABSTRACT
According to clinical characteristics and serum levels of alpha 1-proteinase inhibitor in the acute period (1-3 days), four groups of patients with myocardial infarction were identified. The most severe myocardial infarction was observed in patients from Groups 1 and 4. It was found that the serum alpha 1-proteinase inhibitor ratios in acute myocardial infarction were closely related to its clinical course. In the authors' opinion, determination of alpha 1-proteinase inhibitor titers by the rapid method will allow the goal-oriented therapeutical measures, including inhibitor therapy to be used.
Subject(s)
Myocardial Infarction/drug therapy , alpha 1-Antitrypsin/therapeutic use , Adult , Aged , Female , Humans , Male , Middle Aged , Myocardial Infarction/blood , Prognosis , Time Factors , alpha 1-Antitrypsin/analysisABSTRACT
In 161 patients with acute myocardial infarction, the kallikrein-kinin system was found to be activated. In addition, there were alterations in indices of the coagulative system, which were suggestive of hypercoagulation. The unidirectional changes in the indices of the systems in question during therapy in the periods of rehabilitation are attributable to the common character of trigger mechanisms responsible for their activation and to the involvement of the kinin system in the regulation of hemostatic potential.
Subject(s)
Kallikreins/blood , Kinins/blood , Myocardial Infarction/blood , Adult , Aged , Carboxylic Ester Hydrolases/blood , Enzyme Activation , Female , Humans , Lysine Carboxypeptidase/blood , Male , Middle Aged , Myocardial Infarction/rehabilitation , Peptidyl-Dipeptidase A/blood , alpha 1-Antitrypsin/analysisSubject(s)
Coronary Disease/diagnosis , Myocardial Contraction , Adult , Aged , Echocardiography , Female , Hemodynamics , Humans , Male , Middle AgedSubject(s)
Kallikreins/blood , Kinins/blood , Myocardial Infarction/blood , Adult , Female , Humans , Male , Middle Aged , Myocardial Infarction/complicationsSubject(s)
Ceramics , Pneumoconiosis/therapy , Textile Industry , Adult , Byssinosis/therapy , Female , Humans , Male , Respiratory Therapy/methods , UkraineABSTRACT
The kinin and coagulation functions were examined in 78 myocardial infarction patients in relation to the presence of essential hypertension. The kallikrein-kinin activation and blood hypercoagulation were shown to be more pronounced in cases of associated essential hypertension.