[Clinicofunctional changes of heart in patients with clinically different variants of toxic diphtheria]. / Kliniko-funktsional'nye izmeneniia serdtsa u bol'nykh toksicheskoi difteriei s razlichnymi variantami.

A clinicofunctional examination of 72 patients with toxic diphtheria (mean age 36.8 +/- 7.1 years) has been made to study the course and outcome of diphtheria-related damage to the heart. It is shown that clinical symptoms of myocarditis became more prominent with growing severity of diphtheric infection and evidenced for diffuse affection of the left ventricle. EchoCG detected defective systolic function which in patients with unfavorable prognosis was associated with thickening of the myocardium and dilatation of the left ventricular chamber. 24-h Holter monitoring registered shifts in the end part of the ECG ventricular complex and various abnomalities in the heart rhythm. Focal myocardial lesions manifested with supraventricular and solitary ventricular extrasystoles. In diffuse myocarditis frequent ventricular extrasystoles prevailed. At autopsy, structural myocardial changes in toxic diphtheria were confirmed.

[Prognosis in the treatment outcome of patients with occlusive atherosclerosis of the arteries of lower extremity arteries by evaluation of lipid metabolism]. / Prognozirovanie rezultatov lecheniia bolnykh s ateroskleroticheskimi okkliuziiami arterii nizhnikh konechnostei po pokazateliam lipidnogo obmena.

The authors discuss the results of correlative analysis of the relative content of the main lipid classes in blood of central and regional venous blood flow with the results of treatment of 75 patients with atherosclerosis obliterans of the lower limb vessels in the stage of collateral circulation decompensation. In patients without anatomo-functional reserves of collateral circulation the amount of phospholipids in the venous blood of the affected limb was found to be significantly lower (by more than 22%) than that in blood collected from the vein in the cubital fossa. This regularity may serve as a criterion for prognosticating the results of treatment of patients in the stage of severe decompensation.

[Changes in phosphatidylinositol content in patients with myocardial infarct]. / Issledovanie dinamiki soderzhaniia fosfatidilinozita u bol'nykh s infarktom miokarda.

The changes of phosphatidylinositol content in blood of patients with myocardial infarction was studied. A procedure is developed for multiple estimation of phosphatidylinositol content within short-time intervals which enabled one to obtain additional data on the functional state of biomembranes. In the clinical practice the data obtained may be used for diagnosis and evaluation of efficiency of ischemic heart disease treatment.

[The dynamic change in the content of total lipids in myocardial infarct patients]. / Dinamika izmeneniia soderzhaniia obshchikh lipidov u bol'nykh infarktom miokarda.

The dynamics of the content of total lipids (cholesterol and cholesterol esters) was studied in patients with acute large-focal uncomplicated myocardial infarction in different disease periods. Rapid quantitative changes that occur in the content of cholesterol and its esters in the test groups were established to be characterized by marked specificity and by the form of its own in different disease periods (in the acute period--days 2-5 and on day 15--the health status stabilization). It is advisable that the characteristics of the dynamics of rapid reversible changes in the content of total lipids may be used for estimating the status gravity of patients with uncomplicated large-focal myocardial infarction.

[The dynamics of the blood level of phosphatidylinositol in patients with myocardial infarction]. / Dinamika soderzhaniia v krovi fosfatidilinozita u bol'nykh infarktom miokarda.

Phospholipids, particularly inositol-containing ones, that serve as secondary messengers and bioregulators of fundamental biochemical processes, essentially contribute to the origination of cardiovascular diseases. These compounds are highly labile and the data on their levels in the blood and its components in various cardiovascular conditions are contradictory. This may be explained by the fact that phosphatidylinositol levels change immediately after blood collection. Therefore the authors found it interesting to investigate the time course of this phospholipid levels, that may to a certain measure reflect the pattern of the metabolic disorders present in this case. They suggest a method of multiple measurements of phosphatidylinositol levels, carried out in short intervals, this yielding additional data on the function of biologic membranes, that may be useful in the diagnosis of coronary disease and assessment of the efficacy of treatment of this condition.