[Effect of chronic stimulation of the emotionogenic zones of the hypothalamus on the status of carbohydrate metabolism in the rabbit]. / Vliianie khronicheskogo razdrazheniia émotsiogennykh zon gipotalamusa na sostoianie uglevodnogo obmena u krolikov.

In chronic experiments on rabbits receiving for 3 months low doses of cholesterol (60 mg per 1 kg of body weight daily), a repeated prolonged (2 h daily) intermittent stimulation of negative and positive emotive zones of the hypothalamus through implanted electrodes (eliciting avoidance and self-stimulation reactions correspondingly),--resulted in uniform disturbances of carbohydrate metabolism. There was a significant reduction of glucose tolerance in comparison with the control group of rabbits with implanted electrodes, as well as a gradual development of a slight, but stable neurogenic hyperglycemia. Simultaneously, in both experimental rabbits groups there were an equal increase of alimentary hypercholesterolemia and a development of persistent neurogenic arterial hypertension.

[Effect of prolonged chronic stimulation of positive emotionogenic zones of the hypothalamus on blood lipid levels and arterial pressure]. / Vliianie dlitel'nogo khronicheskogo razdrazheniia polozhitel'nykh émotsiogennykh zon gipotalamusa na soderzhanie lipidov v krovi i uroven' arterial'nogo davleniia.

Chronic experiments on rabbits with electrodes implanted into positive affective zones of the hypothalamus, which provided the reaction of self-stimulation during experimentation have shown that prolonged, discrete (over 2 hours daily), chronic (over 2 months stimulation of these zones in unrestrained animals does not cause stable changes in the content of blood lipids but lead to a significant lowering of arterial blood pressure. Continued stimulation (for one month more) together with daily feeding of rabbits with small doses of cholesterol (60 mg/kg bw) produced the same effect as the stimulation of the negative emotiogenic zones, namely, a greater increase of alimentary hypercholesterolemia than in animals of two control groups (non-operated and with implanted electrodes), as well as arterial blood pressure elevation.

[Vascular reactivity changes in chronic emotional stress of hypothalamic origin]. / Izmenenie sosudistoi reaktivnosti v usloviiakh khronicheskogo émotsional'nogo stressa gipotalamicheskogo proiskhozhdeniia.

The vessels of rabbits undergoing a long irritation of the negative emotional zones of the hypothalamus have shown a tendency to increase a constrictive reaction in response to the quantitatively dozed electrostimulation of the vessel walls. This is expressed in the decrease of the range of the stimulation parametres which cause the weakening reaction during 10 days of emotional stress, and in showing only a constrictory reaction to all the parameters of stimulation during a 4-month stress.

[Change in the cholesterol and triglyceride content in the blood in self-stimulation and avoidance reactions]. / Izmenenie soderzhaniia kholesterina i triglitseridov v krovi pri reaktsiiakh samorazhrazheniia i izbeganiia.

The changes in the blood serum cholesterol and triglyceride content were studied or rabbits of both sexes during reactions of self-stimulation and avoidance. Self-stimulation was accompanied by a significant decrease in the blood serum cholesterol and triglyceride content. During the reaction of avoidance the character of the cholesterol changes varied. The reaction of avoidance of the "agression" type was accompanied by elevated blood serum cholesterol content, whereas the reaction of the "fear" type was associated with a decrease in its content. The maximal changes in the cholesterol and triglyceride content as compared to the initial level were observed in all types of the reactions 15--30 minutes following stimulation.

[Effect of the chronic stimulation hypothalamic negative emotiogenic zones on a change in blood lipid and heparin content and on arterial pressure]. / Vliianie khronicheskogo razdrazheniia otritsatel'nykh émotsiogennykh zon gipotalamusa na izmenenie soderzhaniia lipidov v krovi, geparina i arterial'noe davlenie.

Rabbits kept on a routine diet and subjected, under conditions of free behavior, to long-term chronic (for a period of 4 months) stimulation of hypothalamic zones which give rise to negative emotions had marked stable endogenic hyperlipidemia (hypercholesterolemia, hypertriglyceridemia), a decrease in the blood heparin content, shortening of blood coagulation time, and mild (by 11%) but significant increase of arterial pressure. The extent of these changes differed with the animals. The dynamics of the increase in the blood cholesterol and triglyceride levels differed both in the degree of the increase as compared to the initial levels (by 44 and 74%, respectively) and in the latent period of attaining maximum deviations. There was a definite connection between the changes in the levels of triglycerides and heparin in blood. When rabbits were given small doses of methylthiouracil and stimulation was continued on that background, the blood cholesterol level grew still more (up to 110% of the initial level). The data obtained attest to the role of prolonged emotional stress in the genesis of stable metabolic and vasomotor disorders which may promote the development of preconditions for the origin of such cardiovascular diseases as atherosclerosis, hypertensive disease, and coronary thrombosis.

[The role of prolonged emotional stress in the genesis of hypercholesterolemia and hypertension]. / Issledovanie roli dlitel'nogo émotsional'nogo stressa v geneze giperkholesterinemii i gipertenzii

Stable endogenous hypercholesterolemia and a slight, but stable hypertension developed under conditions of unrestricted behaviour in rabbits subjected for 4 months to daily prolonged (2-hour) interrupted stimulation of negative emotional zones of the hypothalamus through the implanted electrodes. Changes in cholesterol content were more noticable in case the stimulation was continued against the background of daily feeding of these rabbits with small doses of methylthiouracil.