[Iodoantipyrine--an agent for treating and preventing tick-borne encephalitis]. / Iodantipirin--sredstvo dlia lecheniia i profilaktiki kleshchevogo éntsefalita.

The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.

[Treatment of experimental herpesvirus infection with nonsteroidal anti-inflammatory agents]. / Lechenie éksperimental'noi gerpeticheskoi infektsii nesteroidnymi protivovospalitel'nymi sredstvami.

The therapeutic effect of nonsteroid antiinflammatory drugs (pyrazolone and salicylate derivatives) and their combinations with acyclovir was assessed in experimental herpesvirus infection in cell culture and in mice. A combination of 4-iodoantipyrine and acyclovir protected mice from herpesvirus encephalitis. This effect was associated with a decrease of the level of the virus in mouse brain and an increase of the titers of serum interferon and virus neutralizing antibodies.

[The antiviral properties of 4-iodoantipyrine in an experimental enterovirus infection]. / Issledovanie protivovirusnykh svoistv 4-iodantipirina pri éksperimental'noi énterovirusnoi infektsii.

The studies of the therapeutic and prophylactic action of a compound from the group of nonsteroid antiinflammatory substances, iodantipyrine-4, in newborn white mice infected with Coxsackie B3 virus showed the drug to possess both therapeutic and prophylactic activity in the acute period of infection.

[The therapeutic and prophylactic effect of 4-iodoantipyrine in experimental tick-borne encephalitis]. / Lechebnyi i profilakticheskii éffekt 4-iodantipirana pri éksperimental'nom kleshchevom éntsefalite.

The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.

[Immunomodulating properties of non-steroidal anti-inflammatory drugs]. / Immunomoduliruiushchie svoistva nesteroidnykh protivovospalitel'- nykh sredstv.

There has been studied the influence of a number of nonsteroidal antiinflammatory agents (NSAID ) on the humoral immune response of mice in immunization with erythrocytic and viral antigen. It has been found out that NSAID have immunomodulating effect, stimulating humoral immune response (4-iodantipyrine, 4-bromantipyrine) or suppressing it (butadione, sodium salicylate). Apparently the mechanism of NSAID ++ immunostimulating effect is related to the inhibition of T-suppressors ++ function by the latter ones.

[Effect of non-steroidal anti-inflammatory agents on interferon induction]. / Vliianie nesteroidnykh protivovospalitel'nykh sredstv na induktsiiu interferona.

Nonsteroid antiinflammatory agents (NAIA) such as antipyrine, butadion, acetylsalicylic acid, sodium salicylate, stampyrine and 4-iodantipyrine are not interferonogenic. Still, they stimulated interferonogenic action of poly(G).poly(C) in studies on animals. Relation between the interferon-stimulating action of the NAIA and their effect on activity of prostaglandin and the influence on the immune system was suggested.

[Organ culture of the liver of sucklings born to mice infected with viruses during pregnancy]. / Organnaia kul'tura pecheni sosunkov, poluchennykh ot myshei, infitsirovannykh virusom vo vremia beremennosti.

The growth and proliferation of organ liver cultures from sucklings born to mice infected with Coxsackie A 13 virus during pregnancy have been studied. In liver explants of the experimental group of sucklings, a well defined zone of of growth, mostly of epithelial cells, was observed early, whereas the cell growth around liver explants of sucklings born to control female mice was either absent or very weak.

[Course of the rheumatic process in mitral heart defects after primary and repeated courses of treatment with titrated gamma-globulin]. / Techenie revmaticheskogo protsessa u bol'nykh mitral'nymi porokami serdtsa posle pervichnykh i povtornykh kursov lecheniia titrovannym gamma-globulinom.

Titrated gamma-globulin, which the authors used in the preoperative management of patients with acquired valvular disease and minimum rheumatism activity, contained high titers of antibodies against the antigens of streptococcus (streptokinase, streptohyaluronidase, streptolysin 0) and Coxsackie A13, A18, and B3 viruses. Its use in combination with antirheumatic agents did not cause any complications and made it possible to reduce the activity of the process in most cases with grade I and after repeated courses also in grade II activity of rheumatism. Treatment with titrated gamma-globulin stimulates the organism's defence forces (factors of nonspecific immunity: complement, lysozyme, interferon) and leads to diminution of the isolation of cardiotropic viruses from blood and bioptic material of the atria of patients.

[Growth of organ cultures of mouse liver infected with Coxsackie A13 virus]. / Nekotorye osobennosti rosta organnoi kul'tury pecheni myshei, infitsirovannykh virusom Koksaki A13.

Peculiarities attending the growth and proliferation of the organ cultures of the liver of mongrel albino mice infected once with Coxsackie A-13 virus were investigated. A marked zone of growth, mostly of the epithelial cells, was determined rather early in the liver explants of mice in the experimental group, whereas in control group of mice the cell growth around the explant of the liver was either absent or very weak. Besides, a great number of lymphocytes evenly arranged in the zone of hepatocytes growth was observed in the preparations of the experimental mice liver. Lymphocyte "adhesion" to hepatocytes of the culture was revealed in some preparations. Moreover, destruction of the hepatocytes and a marked rarefaction of the cell layer occurred at the sites of lymphocytes accumulation on the 21st and the 28th days of growth.

[Heart lesions in mice with experimental infection caused by Coxsackie virus A13]. / Porazheniia serdtsa u myshei pri éksperimental'noi infektsii, vyzvannoi virusom koksaki A13

The results of pathomorphological and virological studies of experimental Coxsackie A 13 virus infection in BALB/C mice are described. Chronic myocarditis, endocarditis and valvulitis were observed in mice inoculated 10 to 12 hours after birth. The virus was revealed in the infected mice for 15-20 days only.

[Antiviral inhibitor induction under the influence of some anti-inflammatory agents]. / Induktsiia antivirusnykh ingibitorov pod vliianiem nekotorykh protivovospalitel'nykh sredtsv

An investigation into the effect produced by a series of acyl-derivatives of pyrasolone and salicytates on the generation of antiviral inhibitors (AVI) to the RNA and DNA-carrying viruses in the tissue cultures and chick embryos ascertained the active AVI inhibitors to be derivatives of 4-amino- and 4-methylaminoantipyrine, acylated with higher fatty and substituted benzoic acids.