ABSTRACT
AIM: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N). MATERIALS AND METHODS: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day. RESULTS: Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients. CONCLUSION: Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Enalapril/therapeutic use , Hypertension/drug therapy , Administration, Oral , Adolescent , Adult , Angiotensin-Converting Enzyme Inhibitors/administration & dosage , Blood Pressure/drug effects , Diuretics , Drug Therapy, Combination , Enalapril/administration & dosage , Follow-Up Studies , Humans , Hydrochlorothiazide/administration & dosage , Hydrochlorothiazide/therapeutic use , Hypertension/diagnosis , Hypertension/physiopathology , Middle Aged , Safety , Severity of Illness Index , Sodium Chloride Symporter Inhibitors/administration & dosage , Sodium Chloride Symporter Inhibitors/therapeutic use , Treatment OutcomeSubject(s)
Heart/physiopathology , Tetanus/physiopathology , Animals , Catecholamines/blood , Creatine Kinase/blood , Dogs , Electrocardiography , Electrolytes/blood , Humans , Myocardium/pathology , Rabbits , RatsABSTRACT
The intravenous 80 mg/kg injection of isadrine and novodrine decreases the amount of malonic dialdehyde in the rat myocardium tissue, which is explained by the active participation of lipid peroxides of the mitochondrial matrix in the respiratory processes. Beta-adrenoagonists are supposed to promote intensive expenditure of energy and to slow down its production. They may be both antioxidants and prooxidants depending on the dose, way of administration and initial state of the material under study.