ABSTRACT
A survey was conducted among the hemodialysis units of the city of Campo Grande, located in the state of Mato Grosso do Sul in the Mid-west region of Brazil, with the aim of investigating the prevalence, risk factors, and genotypes of hepatitis C virus (HCV) infection. A total of 163 patients were interviewed in five dialysis units. Serum samples were screened for anti-HCV. Positive samples were tested for HCV RNA and genotyped. The prevalence of anti-HCV was 11% (95% CI: 6.8-17.1). A history of transfusion with blood that was not screened for anti-HCV and length of time on hemodialysis were associated with HCV infection. HCV RNA was detected in 12 samples: ten were of genotype 1, subtypes 1a (75%) and 1b (8.3%), and two were of genotype 3, subtype 3a (16.7%).
Subject(s)
Hepacivirus/immunology , Hepatitis C Antibodies/blood , Hepatitis C/epidemiology , RNA, Viral/genetics , Renal Dialysis/adverse effects , Adolescent , Adult , Aged , Aged, 80 and over , Brazil/epidemiology , Enzyme-Linked Immunosorbent Assay , Female , Genotype , Hepatitis C/diagnosis , Hepatitis C/transmission , Humans , Male , Middle Aged , Prevalence , Risk FactorsABSTRACT
A survey was conducted among the hemodialysis units of the city of Campo Grande, located in the state of Mato Grosso do Sul in the Mid-west region of Brazil, with the aim of investigating the prevalence, risk factors, and genotypes of hepatitis C virus (HCV) infection. A total of 163 patients were interviewed in five dialysis units. Serum samples were screened for anti-HCV. Positive samples were tested for HCV RNA and genotyped. The prevalence of anti-HCV was 11 percent (95 percent CI: 6.8-17.1). A history of transfusion with blood that was not screened for anti-HCV and length of time on hemodialysis were associated with HCV infection. HCV RNA was detected in 12 samples: ten were of genotype 1, subtypes 1a (75 percent) and 1b (8.3 percent), and two were of genotype 3, subtype 3a (16.7 percent).