ABSTRACT
BACKGROUND: The aim of this randomized clinical trial follow-up at three months was to evaluate the effectiveness of an educational intervention with a focus on diet and physical activity (PA) to change the amount of PA, body mass index (BMI) and the waist circumference (WC) in patients with severe mental illness. METHODS: We recruited 332 outpatients with severe mental disorders undergoing treatment with antipsychotic medication from Mental Healthcare Centers of Barcelona. They were randomly assigned to an intervention or a control group. The patients in the intervention group participated in a group PA and diet educational program. The blinded measurements at 0 and 3 months were: the level of PA (IPAQ questionnaire), BMI, WC, blood pressure, dietary habits (PREDIMED questionnaire), quality of life (SF-36 questionnaire) and laboratory parameters (cholesterol, triglycerides, glucose). RESULTS: The average age was 46.7 years and 55% were males. Schizophrenia had been diagnosed in 67.1% of them. At 3 months, the average weekly walking METs rose significantly in the IG 266.05 METs (95%CI: 16.86 to 515.25; P=0.036). The total MET average also rose although not significantly: 191.38 METs (95%CI: 1.38 to 381.38; P=0.086). However, the BMI decreased significantly more in the CG, by 0.26kg/m(2) (95%CI: 0.02 to 0.51; P=0.038), than in the IG. There were no significant differences in the WC. CONCLUSIONS: The short-term results suggest that the intervention increases the level of PA, but does not improve physical or laboratory parameters. TRIAL REGISTRATION: Clinicaltrials.gov NCT01729650 (effectiveness of a physical activity and diet program in patients with psychotic disorder [CAPiCOR]).
Subject(s)
Antipsychotic Agents/therapeutic use , Cardiovascular Diseases , Diet Therapy/methods , Exercise Therapy/methods , Psychotic Disorders , Quality of Life , Adult , Body Mass Index , Cardiovascular Diseases/complications , Cardiovascular Diseases/psychology , Cardiovascular Diseases/therapy , Cholesterol/blood , Female , Humans , Male , Middle Aged , Motor Activity/physiology , Psychotic Disorders/complications , Psychotic Disorders/physiopathology , Psychotic Disorders/therapy , Surveys and Questionnaires , Treatment Outcome , Triglycerides/blood , Waist CircumferenceABSTRACT
Entre los efectos adversos de la terapia electroconvulsiva (TEC), las quejas sobre disfunción mnésica son los más frecuentes y relevantes para los pacientes. Tras la TEC, la amnesia anterógrada y retrógrada son más determinantes para la memoria explícita y puede tener un efecto persistente sobre la episódica impersonal. La memoria implícita no suele resultar afectada. Los factores relacionados con más déficit son: TEC bilateral, dosis supraumbral elevada, onda sinusal, 3 tratamientos por semana, alteración cognitiva previa a la TEC y tiempo prolongado en recuperar la orientación tras ésta, agentes anestésicos y edad
One of the most frequent and important complaints made by patients about electroconvulsive therapy (ECT) is memory dysfunction. After ECT, anterograde and retrograde amnesia are more marked for explicit memory, and could have a lasting effect on impersonal episodic memory. Implicit memory is not usually affected. The factors related to severe dysfunction are: bilateral ECT, markedly suprathreshold stimulus, sinus wave, treatment three times per week, cognitive alteration before ECT and prolonged time to recovery of orientation after ECT, anesthetic agents, and age