Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 12 de 12
Filter
1.
Rev Esp Patol ; 56(1): 32-44, 2023.
Article in English | MEDLINE | ID: mdl-36599598

ABSTRACT

Pancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability to predict response to treatment of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion. In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. Based on their results, a series of recommendations are made to optimize the determination of these biomarkers and thus help standardize the diagnosis and treatment of these tumours.


Subject(s)
Biliary Tract Neoplasms , Pancreatic Neoplasms , Humans , Consensus , Biomarkers, Tumor/genetics , Pancreatic Neoplasms/genetics , Medical Oncology , Biliary Tract Neoplasms/diagnosis , Biliary Tract Neoplasms/genetics , Pancreatic Neoplasms
2.
Clin. transl. oncol. (Print) ; 24(11): 2107-2119, noviembre 2022. ilus
Article in English | IBECS | ID: ibc-210139

ABSTRACT

Pancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment.In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours. (AU)


Subject(s)
Humans , Bile Duct Neoplasms/diagnosis , Bile Duct Neoplasms/genetics , Biomarkers, Tumor , Medical Oncology , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/genetics , Consensus
4.
Clin Transl Oncol ; 24(11): 2107-2119, 2022 Nov.
Article in English | MEDLINE | ID: mdl-36008616

ABSTRACT

Pancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment.In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours.


Subject(s)
Biliary Tract Neoplasms , Pancreatic Neoplasms , Biliary Tract Neoplasms/diagnosis , Biliary Tract Neoplasms/genetics , Biomarkers, Tumor/genetics , Consensus , Humans , Medical Oncology , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/genetics , Pancreatic Neoplasms
6.
Rev. esp. enferm. dig ; 111(2): 159-161, feb. 2019. ilus, tab
Article in Spanish | IBECS | ID: ibc-182200

ABSTRACT

La aparición de los nuevos antivirales de acción directa (AAD) para el tratamiento del virus de la hepatitis C (VHC) supone un gran avance para pacientes con hepatitis autoinmune e infectados, ya que hasta el momento no se disponía de opciones terapéuticas libres de interferón. Presentamos el caso de una paciente con infección por VHC que sufrió una HAI desencadenada por interferón, sin conseguir suspender el tratamiento inmunosupresor durante años. Gracias a los AAD, se alcanzó una respuesta viral sostenida y, posteriormente, una remisión clínica completa de su enfermedad autoinmune, sin tratamiento actualmente


The use of direct-acting antivirals (DAA) for the hepatitis C virus (HCV) has yielded a significant improvement in the treatment of autoimmune hepatitis (AIH) associated with HCV infection. Interferon was the cornerstone of HCV therapy before the introduction of these agents into the clinical practice. Herein, we report the case of an HCV-infected patient who developed an interferon-induced AIH and since then, has received immunosuppressive therapy. Administration of DAA resulted in a sustained virologic response (SVR) and clinical AIH remission which allowed a discontinuation of immunosuppressive treatment


Subject(s)
Humans , Female , Middle Aged , Hepatitis C, Chronic/drug therapy , Hepatitis, Autoimmune/drug therapy , Antiviral Agents/therapeutic use , Interferons/therapeutic use , Interferons/adverse effects , Elasticity Imaging Techniques/methods , Liver Cirrhosis/diagnostic imaging
7.
Rev Esp Enferm Dig ; 111(2): 159-161, 2019 Feb.
Article in English | MEDLINE | ID: mdl-30449122

ABSTRACT

The use of direct-acting antivirals (DAA) for the hepatitis C virus (HCV) has yielded a significant improvement in the treatment of autoimmune hepatitis (AIH) associated with HCV infection. Interferon was the cornerstone of HCV therapy before the introduction of these agents into the clinical practice. Herein, we report the case of an HCV-infected patient who developed an interferon-induced AIH and since then, has received immunosuppressive therapy. Administration of DAA resulted in a sustained virologic response (SVR) and clinical AIH remission which allowed a discontinuation of immunosuppressive treatment.


Subject(s)
Antiviral Agents/therapeutic use , Hepatitis C, Chronic/drug therapy , Hepatitis, Autoimmune/drug therapy , Antiviral Agents/adverse effects , Azathioprine/therapeutic use , Benzimidazoles/therapeutic use , Female , Fluorenes/therapeutic use , Hepatitis C, Chronic/complications , Hepatitis, Autoimmune/etiology , Humans , Immunosuppressive Agents/therapeutic use , Interferons/adverse effects , Middle Aged , Prednisone/therapeutic use , Sofosbuvir , Sustained Virologic Response , Uridine Monophosphate/analogs & derivatives , Uridine Monophosphate/therapeutic use
8.
Rev. esp. enferm. dig ; 110(3): 204-206, mar. 2018. ilus
Article in Spanish | IBECS | ID: ibc-171527

ABSTRACT

La adenomatosis hepática es una enfermedad benigna definida por la aparición de múltiples adenomas en un hígado normal. Se trata de una entidad poco frecuente y de causa no conocida, de la que existen menos de un centenar de casos publicados en la literatura médica y que se ha relacionado con la toma de anticonceptivos orales o esteroides anabolizantes, con enfermedades por depósito y con mutaciones genéticas asociadas a la diabetes mellitus tipo MODY (maturity onset diabetes of the young). En los últimos años se ha comunicado la coexistencia de adenomatosis hepática con lesiones de esteatohepatitis no alcohólica en dos pacientes con síndrome metabólico, una asociación de interés por la creciente prevalencia de la enfermedad hepática grasa no alcohólica en los países desarrollados y por la posibilidad de que compartan un mecanismo causal. Comunicamos el caso de una mujer joven con fructosemia familiar y esteatosis hepática durante cuyo seguimiento aparecieron múltiples adenomas hepáticos asociados a lesiones de esteatohepatitis y discutimos el posible significado de dicha asociación (AU)


Hepatic adenomatosis is a benign disease defined as the presence of multiple adenomas in a normal liver. It is an uncommon condition and there are less than a hundred reported cases in the literature. The etiology is unknown, although it has been associated with the use of oral contraceptives, anabolic steroids, certain storage diseases and some genetic mutations linked to maturity onset diabetes of the young. The coexistence of hepatic adenomatosis and nonalcoholic steatohepatitis has been recently described in two patients suffering from metabolic syndrome. This association is particularly interesting due to the growing prevalence of nonalcoholic fatty liver disease in developed countries and the possibility of a common causal pathway. We report the case of a young woman with fructosemia and hepatic steatosis; multiple hepatic adenomas associated to steatohepatitis lesions were also found during clinical follow-up. The possible implications are discussed (AU)


Subject(s)
Humans , Female , Adult , Non-alcoholic Fatty Liver Disease/complications , Adenoma, Liver Cell/complications , Fructose/blood , Mutation/genetics , Genetic Predisposition to Disease , Hepatocyte Nuclear Factor 1-alpha/genetics
9.
Rev Esp Enferm Dig ; 110(3): 204-206, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29277999

ABSTRACT

Hepatic adenomatosis is a benign disease defined as the presence of multiple adenomas in a normal liver. It is an uncommon condition and there are less than a hundred reported cases in the literature. The etiology is unknown, although it has been associated with the use of oral contraceptives, anabolic steroids, certain storage diseases and some genetic mutations linked to maturity onset diabetes of the young. The coexistence of hepatic adenomatosis and nonalcoholic steatohepatitis has been recently described in two patients suffering from metabolic syndrome. This association is particularly interesting due to the growing prevalence of nonalcoholic fatty liver disease in developed countries and the possibility of a common causal pathway. We report the case of a young woman with fructosemia and hepatic steatosis; multiple hepatic adenomas associated to steatohepatitis lesions were also found during clinical follow-up. The possible implications are discussed.


Subject(s)
Adenoma/complications , Liver Neoplasms/complications , Non-alcoholic Fatty Liver Disease/complications , Adenoma/diagnostic imaging , Adenoma/pathology , Adult , Female , Fructose Intolerance/etiology , Hepatocyte Nuclear Factor 1 , Humans , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/pathology , Magnetic Resonance Imaging , Non-alcoholic Fatty Liver Disease/diagnostic imaging , Non-alcoholic Fatty Liver Disease/pathology
10.
Intern Med ; 55(18): 2595-9, 2016.
Article in English | MEDLINE | ID: mdl-27629952

ABSTRACT

Endometriosis is a quite common pathology, however, intestinal endometriosis is a rare condition, which typically occurs with chronic symptoms. Its acute presentation is very infrequent. We herein report four cases of intestinal endometriosis, in which the clinical debut occurred acutely: two as an acute small bowel obstruction and two as a small bowel perforation. None of the cases had a preoperative diagnosis of endometriosis. The interest of these cases lies in this exceptional form of presentation, such as a surgical acute abdomen. Therefore, intestinal endometriosis should be taken into account in the differential diagnosis of an acute obstructive or perforative process of the small or large bowel.


Subject(s)
Endometriosis/complications , Intestinal Obstruction/etiology , Intestinal Perforation/etiology , Abdomen, Acute/etiology , Acute Disease , Adult , Colectomy , Diagnosis, Differential , Endometriosis/surgery , Female , Humans , Intestinal Obstruction/diagnosis , Intestinal Obstruction/surgery , Intestinal Perforation/diagnosis , Intestinal Perforation/surgery , Intestine, Small/pathology , Middle Aged
11.
World J Gastrointest Oncol ; 5(7): 159-70, 2013 Jul 15.
Article in English | MEDLINE | ID: mdl-23919110

ABSTRACT

Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, the extrahepatic hilar CC. Grossly, a major distinction can be made between papillary and non-papillary tumors. Histologically, most hilar CCs are well to moderately differentiated conventional type (biliary) carcinomas. Immunohistochemically, CK7, CK20, CEA and MUC1 are normally expressed, being MUC2 positive in less than 50% of cases. Two main premalignant lesions are known: biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the biliary tract (IPNB). IPNB includes the lesions previously named biliary papillomatosis and papillary carcinoma. A series of 29 resected hilar CC from our archives is reviewed. Most (82.8%) were conventional type adenocarcinomas, mostly well to moderately differentiated, although with a broad morphological spectrum; three cases exhibited a poorly differentiated cell component resembling signet ring cells. IPNB was observed in 5 (17.2%), four of them with an associated invasive carcinoma. A clear cell type carcinoma, an adenosquamous carcinoma and two gastric foveolar type carcinomas were observed.

12.
Acta Cytol ; 46(6): 1153-7, 2002.
Article in English | MEDLINE | ID: mdl-12462099

ABSTRACT

BACKGROUND: Paget's disease of the vulva (PDV) is a rare entity, with only a few cytologic descriptions having been published on it. Diagnosis is usually delayed because it is often clinically mistaken for some types of dermatosis, and biopsy is usually postponed. CASE: A 56-year-old woman presented with a pruritic, erythematous and ulcerated superficial lesion on the right labium majus of approximately eight months' duration. A vulvar cytologic smear showed a bloody and inflammatory background with many single malignant cells; scarce malignant cell aggregates; and abundant, mature squamous and dyskeratotic cells. The tumor cells were large, with a frequently eccentric, large nucleus. Some binucleated forms were noted. Nucleoli were rare. Cytoplasm varied from pale and delicate to densely basophilic. Intracytoplasmic vacuoles were very rare. Tumor cell aggregates were small and exhibited pseudocannibalism. Short strands of malignant cells arranged in an Indian file pattern were also evident. Histologic examination of a wedge biopsy, wide local excision of the lesion and simple vulvectomy showed PDV. CONCLUSION: Knowledge of the cytologic features of PDV could provide a highly probable cytologic diagnosis of the disease and should alert the clinician to the need for immediate biopsy. Systematic collecting of smears from any eczematous change in the vulva should be considered a first step to early diagnosis of malignancy.


Subject(s)
Paget Disease, Extramammary/pathology , Vulvar Diseases/pathology , Female , Humans , Middle Aged , Vulva/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...