[Changes in the nonspecific factors of body protection in experimental Salmonella infection]. / Izmenenie nekotorykh nespetsificheskikh faktorov zashchity organizma pri éksperimental'noi sal'monelleznoi infektsii.

Cytochemical studies of the components of intracellular microbicidal system of leukocytes were performed on rabbits. Two experimental models of Salmonella infection were used. With the oral infection by S. typhimurium the mild form of experimental salmonellosis was noticed. The decrease in myeloperoxidase activity and cation protein and lipid content, as well as an increase in glycogen content and NBT-test activity were observed. Intravenous injection of S. typhimurium endotoxin produced the clinical pattern of endotoxin shock. The activity of all the variables tested was decreased. It returned to standard values 120-240 hours after endotoxin injection.

[Changes in the nephron and neuroendocrine apparatus of the kidneys following the administration of Salmonella endotoxin]. / Izmeneniia nefrona i neiroéndokrinnykh apparatov pochek posle vvedeniia sal'monelleznogo éndotoksina.

Electron microscopy was used to examine renal glomerules and tubules, as well as the renal neuro-endocrine apparatus 3 and 24 hours after intravenous injection of 2 mg/kg S. typhimurium endotoxin. The studies demonstrated swelling and vacuolization of the endothelial cells and an increase in the glomerular capillaries of the number of polymorphonuclear leukocytes with lysosomal sequestration and fibrin emergence 3 hours after endotoxin injection, intravascular coagulation, accumulation of polymorphonuclear leukocytes in the peritubular capillaries, fat dystrophy of the mesangial cells and nephrocytes in the proximal tubules after 24 hours. The method for mathematical estimation of granulation in the juxtaglomerular apparatus (JGA), designed by the authors, from the density of the contents of epithelioid cell granules enabled the detection of JGA activation, particularly 24 hours after endotoxin injection. The reduction of the number of granules in the interstitial cells of the renal medulla might be due both to JGA activation and endotoxin action that stimulates the synthesis of prostaglandins.