ABSTRACT
The study deals with antitumor action of soybean proteins as natural bio-mediators for alleviating side-effects of chemotherapy. The influence of soybean proteins on antibody formation and free-radical mechanisms in blood serum was assessed in melanoma B-16-bearing mice. Use of soybean proteins was followed by a 65% rise in inhibition of tumor growth and an 1.4-fold increase in survival time. In particular, an enhanced level of antibody formation cells in the spleen and normalization of oxidative processes in blood serum were reported.
Subject(s)
Cell Division/drug effects , Free Radicals/blood , Melanoma, Experimental/pathology , Soybean Proteins/pharmacology , Animals , Mice , Mice, Inbred C57BLABSTRACT
The development of a malignant process and antitumor treatment leads to the occurrence of a variety of complications. It is expedient to use biological regulators of natural origin to eliminate the side effect of chemical drugs and to improve the outcomes of antitumor therapy. The antitumor effect of soya proteins and their influence on antibody formation and oxidative processes in the sera of tumor-bearing animals were investigated. Soya proteins are shown to retard the development of a tumorous process, modulate the therapeutic effect of 5-fluorouracil, enhance antibody formation, and normalize serum oxidative processes.
