[Genetic demographic study of an urban sample of Turkmen-teke with behavioral abnormalities]. / Genetiko-demograficheskoe izuchenie gorodskoi vyborki turkmen-teke s anomaliiami povedeniia.

Genetic and demographic studies of urban sample of Turkmen-teke (Ashkhabad city) were performed among probands-36 patients with diagnosis of "schizophrenia" and their 840 relatives. Clinical analysis revealed 27.8% of phenocopies. In other 26 families the genealogical analysis showed autosomal-dominant (12 families), probably, autosomal-dominant (9 families) as well as autosomal-recessive (3 families) types of inheritance of pathology, in two families the type being not established. The empiric risk of affection was determined to be 24.2% for parents, 75.5% for sibs and 33.3% for children. Mean number of children per one woman is 3.53, which is significantly lower than mean populational number (6.17). High level of endogamy of the urban sample tested is established, the total coefficient of inbreeding being 0.009856; grandparents of the probands appeared to be exclusively of rural origin. The negative action of selection (decreased fitness), preferentially monogenic type of heredity and high level of endogamy are discussed as factors providing broad hereditary heterogeneity of schizophrenia.

[Population and demographic study of the Turkmen Tekke]. / Populiatsionno-demograficheskoe izuchenie turkmen teke.

Genetical and demographic studies of typical rural population of Turkomen teke in Yangi-Kala village of the Ashkhabad region (about 5.000 inhabitants) were performed through the examination of a sample of 3528 persons. The population is characterised by intensive growth (mean number of children per one woman is 6.17), a high level of endogamy (the total coefficient of inbreeding being 0.010912), preserving the traditional marriage system (91.9 and 8.1% of intrageneric and intergeneric marriages, respectively). Migration does not significantly influence endogamy, because it takes place among kin families.