ABSTRACT
Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. Methods: The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn't show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.
