1.
Org Biomol Chem
; 15(2): 360-372, 2017 Jan 04.
Article
in English
| MEDLINE
| ID: mdl-27910982
ABSTRACT
A synthetic approach to the 6-methyl-3,4-dihydropyrazinone core from Ugi adducts is described. This methodology relies on the regioselective C-N bond formation between an allenamide moiety at C-ß and an amide anion formed under base-mediated conditions. This protocol allows easy access to tricyclic systems such as pyrazino[2,1-a]isoindole and pyrazino[2,1-a]isoquinoline nuclei.