1.
Neurologist
; 13(2): 83-6, 2007 Mar.
Article
in English
| MEDLINE
| ID: mdl-17351528
ABSTRACT
We examined the effect of tacrolimus on myasthenia gravis (MG). Five patients with thymoma and 5 patients without thymoma underwent prior thymectomy but showed persistent myasthenic symptoms. Oral administration with tacrolimus significantly improved MG scores 1, 3, and 6 months following the beginning of treatment in all patients (P < 0.05), and the improvement was significantly higher in the thymoma group compared with the nonthymoma group (P < 0.05). However, there was no significant change in antiacetylcholine receptor titers in either group. This indicates a particular application of immunosuppressive therapy for thymomatous MG following thymectomy.
Subject(s)
Immunosuppressive Agents/administration & dosage , Myasthenia Gravis/complications , Myasthenia Gravis/therapy , Tacrolimus/administration & dosage , Thymoma/complications , Administration, Oral , Adult , Aged , Autoantibodies/blood , Autoantibodies/drug effects , Autoantibodies/immunology , Autoimmunity/drug effects , Autoimmunity/immunology , Female , Humans , Male , Middle Aged , Myasthenia Gravis/immunology , Receptors, Nicotinic/immunology , Thymoma/immunology , Thymoma/radiotherapy , Treatment Outcome
2.
Nihon Naika Gakkai Zasshi
; 93(2): 364-6, 2004 Feb 10.
Article
in Japanese
| MEDLINE
| ID: mdl-15007944