ABSTRACT
The oral LD50 of indomethacin for a seven-day observation was found to be 12.58 +/- 1.15 mg/kg. At LD10 of 6.61 mg/kg, a dose to weight ratio of 28 was obtained for a 240 g rat, while at a maximum single dose of 3 mg/kg in man it is only 0.04. Neither diazepam nor phenobarbital influenced death at the doses of both drugs used. However, cholestyramine 2 g/kg/day was found to protect by 50% from the LD100 of indomethacin. Gross pathological studies showed dose-dependent ulceration and perforation (P < 0.001, 12 vs 24 mg/kg) and such lesions occurred in starved rats, were low in bile duct-ligated compared to sham-operated rats (P < 0.001) and were also low in cholestyramine-treated rats. Indomethacin-induced lethality in rats was found to be dose-dependent.
Subject(s)
Indomethacin/toxicity , Rodenticides/toxicity , Administration, Oral , Animals , Bile Ducts/surgery , Body Weight/drug effects , Cholestyramine Resin/pharmacology , Diazepam/pharmacology , Drug Interactions , Female , Lethal Dose 50 , Male , Peptic Ulcer Perforation/chemically induced , Peptic Ulcer Perforation/pathology , Peptic Ulcer Perforation/prevention & control , Phenobarbital/pharmacology , Rats , Rats, Wistar , Rodent Control/methods , Stomach Ulcer/chemically induced , Stomach Ulcer/pathology , Stomach Ulcer/prevention & control , Toxicity TestsABSTRACT
A one year prospective study was carried out to compare clinical diagnosis antemortem with autopsy diagnosis post-mortem in all patients coming to autopsy. In the study period a total of 612 deaths occurred in the hospital out of which 179 came to autopsy representing an autopsy ratio of 29%. Of the 179 cases, 100 (56%) were cases referred to the coroner. A total of 143 cases were analyzed and the concordance rate between clinical and autopsy diagnosis was found to be 54%. We find the autopsy ratio abysmally low and recommend that all effort be made to increase it to 75% and that autopsy audit be officially adopted as a means of quality control in hospitals. We also believe that all concerned should work towards improving our clinical diagnostic ability in order to attain and maintain a concordance rate well above 90%.
Subject(s)
Autopsy/standards , Cause of Death , Coroners and Medical Examiners , Hospital Mortality , Hospitals, Teaching , Humans , Medical Audit , Nigeria , Prospective Studies , Quality Assurance, Health CareABSTRACT
The study was to determine possible pathological changes induced by the consumption of C. icaco and possible health implication. Animal feed tests were carried out using varying amounts of the seed mixed with usual mice meals. The result revealed weight loss; and increase in total bilirubin; protein; albumin; globin; cholesterol level; alkaline phosphate and mean serum glutamic - oxaloacetate transaminase and serum glutamic - pyruvic transaminase activities. Possible health implications are discussed
