Application of Mesenchymal Stem Cells and Exosome alone or Combination Therapy as a Treatment Strategy for Wound Healing.

The process of wound healing consists of multiple phases, and any disruptions in these phases can lead to the wound becoming chronic and impose heavy financial and psychological costs on the patient and a huge economic burden on the country's healthcare system. Various treatments such as drugs, matrix and scaffolds, blood products, cell therapy, and a combination of these treatments are used for wound healing. The use of mesenchymal stem cells (MSCs) is one of these methods that have produced appropriate responses in the healing of patients' wounds. MSCs by secreting growth factors, cytokines, chemokines, and RNAs elicit changes in cell proliferation, migration, growth, signaling, immunomodulation, and wound re-epithelialization process, and as a result, accelerate wound closure and wound healing. These cells can be isolated from different body sources with different cell characteristics and used directly on the wound site or by injection. In addition, MSCs-derived exosomes have attracted growing attention due to circumventing concerns relating to the direct use of MSCs. To increase the performance of MSCs, they can be used together with other compounds such as platelets, matrices, or scaffolds. This study examined the functions of MSCs in wound healing, as well as the vesicles they secrete, cellular and molecular mechanisms, and combined treatments with MSCs for wound healing.

Recent trends in incorporation of CO2 into organosulfur compounds via C-S bond cleavage.

Desulfurative functionalization of organosulfur compounds to form various carbon-carbon and carbon-heteroatom bonds has become established as a powerful tool in organic chemistry. In this context, desulfurative carboxylation of this class of compounds using carbon dioxide (CO2) as a sustainable and renewable source of carboxyl has recently been developed as an efficient option for the synthesis of carboxylic acid derivatives. The aim of this Focus Review is to summarize the major progress in this appealing research field with particular emphasis on the mechanistic features of the reactions. Literature has been surveyed until the end of February 2024, according to the data collected using SciFinder and Google Scholar engines.