ABSTRACT
BACKGROUND: To compare the efficacy, cosmesis and tolerance of two non-surgical treatments-imiquimod (IMQ) 5% cream and radiotherapy (RT)-to combat periocular nodular basal cell carcinoma (BCC). METHODS: Twenty-seven patients with clinical and histopathological diagnosis of nodular BCC on the eyelid were included and randomly selected: 15 patients were treated with IMQ 5% cream once daily, 5 days/week for 6 weeks, and 12 patients were treated with RT. RESULTS: All tumours showed histopathological remission within 3 months of the treatment, and sustained clinical remission was documented in each patient after 24 months' follow-up. Treatment tolerability was rated as moderate with IMQ and good with RT. Functional results were better in patients treated with IMQ. Loss of eyelashes was reported for most of the patients treated with RT. CONCLUSIONS: IMQ and RT therapies are effective for treating eyelid nodular BCCs. Cosmesis and functional results were better with IMQ, while tolerability was higher with RT.
Subject(s)
Aminoquinolines/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Carcinoma, Basal Cell/radiotherapy , Eyelid Neoplasms/drug therapy , Eyelid Neoplasms/radiotherapy , Aged , Aged, 80 and over , Aminoquinolines/adverse effects , Antineoplastic Agents/adverse effects , Carcinoma, Basal Cell/pathology , Eyelid Neoplasms/pathology , Female , Follow-Up Studies , Humans , Imiquimod , Male , Middle Aged , Prospective Studies , Remission Induction , Treatment OutcomeABSTRACT
PURPOSE: To study the ability of Heidelberg Retina Tomography III (HRT 3) measurements to predict perimetry changes in patients with early glaucoma or suspected primary open-angle glaucoma. MATERIAL AND METHODS: One hundred and thirty two eyes with early glaucoma or suspected glaucoma with no changes in basal perimetry were prospectively selected and periodically evaluated over five years. The eyes were divided in two groups depending on the presence or absence of progression (changes in glaucoma perimetry). The association between morphometric parameters and baseline HRT 3 indices, glaucoma probability score (GPS) and Moorefield's Regression Analysis (MRA), and perimetry progression were studied using Cox multivariate regression analyses. Kaplan-Meier curves were used to illustrate the results. RESULTS: Forty-eight eyes (36.36%) showed perimetry progression. Perimetry progression showed higher correlations with the disc area (p = 0.001), the cup area (p = 0.002) and the vertical cup disc area (p = 0.001). Multivariate regression analyses showed that eyes with baseline MRA or baseline GPA changes were at a higher risk of having perimetry abnormalities and a faster progression. CONCLUSIONS: MRA and GPA indices are useful to predict perimetry progression in patients with early primary open-angle glaucoma or suspected glaucoma. These indices can be used as risk markers of functional progression in glaucoma.
Subject(s)
Glaucoma/pathology , Microscopy, Confocal , Adolescent , Adult , Aged , Disease Progression , Glaucoma, Open-Angle/pathology , Humans , Middle Aged , Predictive Value of Tests , Prospective Studies , Young AdultABSTRACT
Objetivo: Determinar si las mediciones de la papila obtenidas con el Heidelberg Retina TomographIII (HRT 3) tienen valor predictivo respecto a las alteraciones del campo visual enpacientes sospechosos de desarrollar glaucoma o con glaucoma incipiente.Material y métodos: Estudio prospectivo de cohortes en el que 132 ojos sospechosos de glaucomao con glaucoma incipiente y una campimetría basal normal o con cambios incipientes,fueron evaluados periódicamente durante 5 años y se dividieron en pacientes conprogresión (cambios glaucomatosos perimétricos) o sin ella.La asociación entre los parámetros morfométricos y los índices glaucoma probability score(GPS) y Moorfields regression analysis (MRA) obtenidos de forma basal con el HRT 3 y la progresióncampimétrica se estudió mediante el modelo de regresión multivariante de Cox. Seutilizaron curvas de Kaplan-Meier para ilustrar los resultados.Resultados: Cuarenta y ocho ojos (36,36%) mostraron progresión. Los parámetros morfométricosque mejor se correlacionaron con la progresión fueron el área de disco (p = 0,001), elárea de excavación (p = 0,002) y el área excavación/disco vertical (p = 0,001). En el modelode regresión multivariante, los ojos con MRA inicial fuera de los límites normales o GPAinicial patológico o borderline, mostraron mayor tendencia a la progresión y ésta tuvo lugaren menos tiempo.Conclusiones: Los índices GPA y MRA son predictivos de aparición de alteraciones en elcampo visual en pacientes con glaucoma incipiente o sospechosos de desarrollarlo, y puedenser útiles para estimar el riesgo de progresión funcional en el glaucoma(AU)
Purpose: To study the ability of Heidelberg Retina Tomography III (HRT 3) measurements topredict perimetry changes in patients with early glaucoma or suspected primary openangleglaucoma.Material and methods: One hundred and thirty two eyes with early glaucoma or suspectedglaucoma with no changes in basal perimetry were prospectively selected and periodicallyevaluated over five years. The eyes were divided in two groups depending on the presenceor absence of progression (changes in glaucoma perimetry).The association between morphometric parameters and baseline HRT 3 indices, glaucomaprobability score (GPS) and Moorefields Regression Analysis (MRA), and perimetryprogression were studied using Cox multivariate regression analyses. Kaplan-Meier curveswere used to illustrate the results.Results: Forty-eight eyes (36.36%) showed perimetry progression. Perimetry progressionshowed higher correlations with the disc area (p = 0.001), the cup area (p = 0.002) and thevertical cup disc area (p = 0.001). Multivariate regression analyses showed that eyes withbaseline MRA or baseline GPA changes were at a higher risk of having perimetryabnormalities and a faster progression.Conclusions: MRA and GPA indices are useful to predict perimetry progression in patientswith early primary open-angle glaucoma or suspected glaucoma. These indices can beused as risk markers of functional progression in glaucoma(AU)
