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1.
A bioanalytical method for the monitoring of metal alkyls in solution.
Bragadin, M; Marton, D; Iero, A; Manente, S; Perin, G; Rizzoli, V; Scutari, G.
Anal Biochem ; 269(2): 420-3, 1999 May 01.
Article in English | MEDLINE | ID: mdl-10222020

Subject(s)
Biosensing Techniques , Organometallic Compounds/analysis , Alkylation , Animals , Environmental Monitoring/methods , In Vitro Techniques , Mitochondria, Liver , Rats , Solutions , Water Pollutants, Chemical/analysis
2.
An in vitro study on the toxic effects of nonylphenols (NP) in mitochondria.
Bragadin, M; Perin, G; Iero, A; Manente, S; Rizzoli, V; Scutari, G.
Chemosphere ; 38(9): 1997-2001, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10101855

ABSTRACT

This paper is focused on alkylphenols, compounds which are formed by the biodegradation of polyethoxilatedalkylphenols detergents. Our experiments show that alkylphenols act not only as detergents, but also as uncouplers of the oxidative phosphorylation. This effect, can be observed at very low doses, thus suggesting that the preferential target of nonylphenols in living organisms are mitochondria.


Subject(s)
Detergents/toxicity , Mitochondria/metabolism , Phenols/toxicity , Animals , Biodegradation, Environmental , Detergents/pharmacokinetics , Dose-Response Relationship, Drug , Liver/drug effects , Mitochondria/drug effects , Phenols/pharmacokinetics , Rats , Rats, Wistar , Uncoupling Agents/metabolism
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