ABSTRACT
OBJECTIVE: Hepatitis C virus (HCV) infection is a major public health problem that causes multiple comorbidities. People in prisons who inject intravenous drugs are at increased risk of HCV infection, and HCV infection is 15-fold more prevalent among prisoners compared with the community. The objective of this study was to analyse the clinical and epidemiological characteristics of residents of a Spanish prison with HCV infection who received antiviral treatment. METHODS: An observational, descriptive and retrospective study was performed. All patients with HCV infection diagnosed or followed up in an Infectious Diseases attached to a penitentiary were included in this study. RESULTS: Of 81 patients analysed, sixty-nine (83.1%) patients were male. The mean age was 50.1 (SD8.8) years, and 70% of the inmates had a history of injection drug use. Coinfection with HIV was detected in 30%. In up to 25% of the sample, there were data on chronic liver disease in the degree of liver cirrhosis. The diagnosis of HCV infection had been made more than 15 years earlier in 28% of those studied. Decompensations from liver disease, hepatocellular carcinoma, or hospital admissions were exceptional. Most of the inmates with HCV accepted treatment, and approximately 94% of the patients who completed treatment achieved a sustained virological response without interactions or complications of interest. CONCLUSIONS: The availability of direct-acting antivirals and their exceptional side effects constitute an opportunity to reduce the burden of HCV infection in Spain, particularly in these high-risk populations.
Subject(s)
Hepatitis C, Chronic , Hepatitis C , Antiviral Agents/therapeutic use , Female , Hepacivirus , Hepatitis C/complications , Hepatitis C/drug therapy , Hepatitis C/epidemiology , Hepatitis C, Chronic/drug therapy , Hepatitis C, Chronic/epidemiology , Humans , Male , Middle Aged , Prisons , Retrospective StudiesSubject(s)
Kidney Transplantation , Postoperative Complications/diagnosis , Tuberculoma, Intracranial/diagnosis , Tuberculosis, Laryngeal/diagnosis , Adult , Aged , Antitubercular Agents/therapeutic use , Cerebellum/microbiology , Cerebellum/pathology , Female , Frontal Lobe/microbiology , Frontal Lobe/pathology , Humans , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Latent Tuberculosis/diagnosis , Male , Occipital Lobe/microbiology , Occipital Lobe/pathology , Polycystic Kidney, Autosomal Recessive/surgery , Tuberculoma, Intracranial/etiology , Tuberculosis, Laryngeal/etiology , Tuberculosis, Pulmonary/complicationsABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Adult , Aged , Kidney Transplantation , Tuberculosis/epidemiology , Renal Insufficiency, Chronic/complicationsABSTRACT
No disponible