ABSTRACT
The authors describe a case of radiation retinopathy after brachytherapy for uveal melanoma successfully treated with nepafenac 0.1%, a non-steroidal anti-inflammotory agent.
Subject(s)
Benzeneacetamides/administration & dosage , Brachytherapy/adverse effects , Melanoma/radiotherapy , Phenylacetates/administration & dosage , Uveal Neoplasms/radiotherapy , Administration, Topical , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Brachytherapy/methods , Female , Humans , Instillation, Drug , Macular Edema/diagnosis , Macular Edema/etiology , Macular Edema/therapy , Melanoma/pathology , Middle Aged , Tomography, Optical Coherence/methods , Treatment Outcome , Uveal Neoplasms/pathologyABSTRACT
AIM: to determine the frequency and severity of dry eye syndrome (DES) in primary open-angle glaucoma (POAG) patients that are newly diagnosed or already receiving beta blocker instillation therapy. MATERIAL AND METHODS: A total of 127 patients (190 eyes) with POAG were divided into two groups. Group 1 included 55 newly diagnosed patients (88 eyes), group 2-72 POAG patients (102 eyes) instilling timolol 0.5% twice daily into the affected eye. The control group included 20 patients (40 eyes) aged 60-88 years (73.6 ± 9.2 years on average) with early age-related cataract. RESULTS: DES was found in 69 POAG patients (79%) who was just starting their topical hypotensive therapy and 85 of those (84%) under treatment (p = 0.39). CONCLUSIONS: One should take into account when prescribing ocular hypotensive therapy that newly diagnosed POAG patients usually already suffer from a dry eye. The use of topical beta blockers that contain preservatives exacerbates dry eye signs and symptoms in these patients.
Subject(s)
Dry Eye Syndromes/epidemiology , Glaucoma, Open-Angle/complications , Adult , Aged , Aged, 80 and over , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/etiology , Female , Glaucoma, Open-Angle/physiopathology , Humans , Incidence , Intraocular Pressure , Male , Middle Aged , Russia/epidemiologyABSTRACT
Proximate causes of intraocular pressure (IOP) decompensation accompanied with persistent pain syndrome were determined based on results of morphological examination of 59 eyes enucleated due to terminal previously operated glaucoma and medical history analysis. Excessive scarring, formation of solid hyalinized membrane in the site of filter pad, closure of anterior chamber angle with synechia as an outcome of chronic iridocyclitis and inappropriate surgical approach lead to increase in the resistance of the aqueous humor outflow and result in glaucoma decompensation causing complications that necessitate enucleation. The most common complications are the following: bacterial corneal ulcer with potential perforation and endophthalmitis, hemorrhagic choroidal detachment, vitreous hemorrhage, persistent pain syndrome and phthisis bulbi.
