[The effect of water-soluble sorbents on the exocrine function of the liver]. / Deistvie vodorastvorimykh sorbentov na vneshnesekretornuiu funktsiiu pecheni.

The effect of water-soluble sorbents on exocrine function of the liver was studied in chronic experiments on 2 dogs with a brought out bile duct. It is shown that choline and digitonin sorbents exhibit choleretic properties similar to those of cholestyramine. Choline sorbent causes a drop in the concentration of (2-4-fold) cholic acid in the bile unlike digitonin sorbent. No prolonging action was seen upon cholestyramine administration, while choline sorbent do demonstrate it. Cholesterol and bilirubin levels do not respond noticeably to the above sorbents.

[Effects of glutamic acid and glutathione on the secretory function of the stomach]. / Vliianie glutaminovoi kisloty i glutationa na sekretornuiu funktsiiu zheludka.

Experiments on dogs with Pavlov isolated pouches and gastric fistulas have shown that the ingested solution of MSG produces a potentiating effect on maximal gastric secretion caused by pentagastrin. This effect is apparently connected with the formation of glutathione in intestine. The glutathione concentration in blood after the intake of MSG is significantly elevated. It has been established that reduced glutathione administered in blood produced the similar potentiating effect on gastric secretion caused by pentagastrin.

[Glutathione participation in regulating the secretory function of the stomach]. / Uchastie glutationa v reguliatsii sekretornoi funktsii zheludka.

In experiments on dogs with Pavlov's pouches it was shown that glutathione infusion into the blood produced a highly pronounced stimulating effect on the gastric secretion induced by pentagastrin. Endogenous glutathione produced similar effect. It was found that intake as a drink of mono-sodium glutamate led to a significant increase of glutathione concentration in the dogs' blood, that was, probably, the result of its intensified production in the intestinal wall and passing into the blood. The growth of glutathione concentration in the blood coincided with its stimulating effect on the gastric secretion. Glutathione administered separately into the blood, or intake of glutathione without pentagastrin did not produce stimulating effect on gastric secretion. The data presented have evidenced that glutathione, besides its known functions, plays a role of the factor engaged in the regulation of gastric secretion.

[Effects of parenterally administered dicarboxylic amino acids and their amides on the secretory function of the stomach]. / Vliianie parental'no vvedennykh dikarbonovykh aminokislot i ikh amidov na sekretornuiu funktsiiu zheludka.

The effect of dicarboxylic amino acids and their amides on gastric secretion stimulated by sham-feeding (100 g of raw meat), as well as of amides of dicarboxylic amino acids on the gastric secretory function was studied in 119 tests on 8 dogs with gastric fistulas according to Basov. The tests were started 16-18 h after feeding under neutral or alkaline reactions of gastric excretion. The tests demonstrated that dicarboxylic amino acids inhibited gastric secretion induced by sham-feeding. It was shown that dicarboxylic amino acid amines, in contrast to these amino acids, did not inhibit gastric secretion induced by sham-feeding. On the contrary, asparagine and glutamine administered into the blood are capable of inducing gastric secretion, per se.

[Mechanism of the action of amino acids on gastric secretion]. / K mekhanizmu deistviia aminokislot na zheludochnuiu sekretsiiu.

The experiments on dogs using gastrin inhibitors (Milid, secretin) and the data of radioimmunoassay on gastrin blood levels have shown that gastrin is not involved into the activation of gastric glands after parenteral injection of amino acids.

[Effect of carbon branched-chain amino acids on gastric secretion]. / Vliianie aminokislot s razvetvlennoi uglerodnoi tsep'iu na zheludochnuiu sekretsiiu.

Experiments on dogs with Basov's gastric fistulas were made to study the effect of amino acids with branched carbon chains (L-isoleucine, L-leucine, L-valine) on gastric secretion. The mixture of amino acids in a concentration of 0.16 M exerts a powerful enough stimulant action, provoking gastric secretion amounting to 2/3 of the value obtained during sham meat feeding. The value of the secretion determined by other amino acids (L-alanine, L-proline) was the same. Unlikely, gastric secretion provoked by glycine (0.16 M) was approximately 1.5 times more intense as compared to that induced by the mixture of amino acids with branched carbon chains. The intense action of glycine is likely to be related to the fact that, apart from the properties common to other amino acids, it possesses the properties of neurotransmitters. L-glutamic acid (0.1 M) administered to the blood produces marked inhibition of gastric secretion caused by the mixture of amino acids with branched carbon chains and the same inhibition of secretion due to administration of other amino acids.