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[Genetic risk factors for multiple sclerosis in the population of Altay].

Smagina, I V; El'chaninova, S A; Zolovkina, A G; Ignatova, Iu N; Kudriavtseva, E A.

Zh Nevrol Psikhiatr Im S S Korsakova ; 111(5): 42-5, 2011.

Article in Russian | MEDLINE | ID: mdl-21666592

ABSTRACT

The "case-control" research in Russian Altai territory population has proved that DR15 and DR3 as well as the combination of female sex and alleles A of TNFα of rs1800629 locus are associated with high risk of multiple sclerosis. The relationship between disease and CD40 polymorphism (rs6074022) was not found.

Subject(s)

HLA-DR Antigens/genetics , Multiple Sclerosis/epidemiology , Multiple Sclerosis/genetics , Tumor Necrosis Factor-alpha/genetics , Adult , Alleles , CD40 Antigens/genetics , Female , HLA-DRB1 Chains , Humans , Male , Middle Aged , Polymorphism, Genetic , Risk Factors , Siberia/epidemiology

ABSTRACT

Subject(s)

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