Artificial aging of mice.

Clinical signs of aging verified by morphometrical analysis of brain tissue were observed in young mice 4 months after administration of brain extract from old mice (5 intraperitoneal injections).

[Gliosis as a trigger of pathomorphological changes in prion diseases]. / Glioz kak puskovoi mekhanizm patomorfologicheskikh izmenenii pri prionnykh bolezniakh.

Experiments with three cell lines revealed that the scraplecontaining cerebral extract, obtained from preliminarily infected 6-month mice, sharply induced the cellular proliferation, which was registered yet in 3 days after incubation. However, the cerebral extract of healthy 6-month mice did not virtually influence the velocity of cells' reproduction in all three cultures. The authors suggest, with respect to published data and to their independently found research results, that the gliosis of primary importance in shaping up the pathomorphological alterations in the cerebral tissue in prion diseases of man and animal.

[Persistence of the influenza virus in children with congenital CNS pathology]. / Persistentsiia virusa grippa u detei s vrozhdennoi patologiei TsNS.

Sick infants born to mothers who experienced influenza during pregnancy were examined. The cerebrospinal fluid, serum and blood cells were collected from such children with signs of congenital immune deficiency and progressive pathology of the central nervous system. None of the specimens yielded infectious influenza virus, but by means of molecular hybridization virus-specific genetic sequences were found in small amounts in the cerebrospinal fluid and serum and in high concentrations in blood cells. Persistence of genes NP, M and H1 of influenza A/H1N1 virus was observed in the blood cells of one infant for 83 days (the observation period). At the same time, the lack of antibodies to viral M protein in serum of this baby was demonstrated by the immune blotting method.