ABSTRACT
Skeletal metastases from prostate cancer is common and usually do not pose a diagnostic dilemma. This study reviews radiographic appearances of prostatic metastases to the appendicular skeleton in four patients where the appearances simulated osteosarcoma, Paget's disease and Paget's sarcoma. Prostatic metastases to long bones can produce appearances considered characteristic of other lesions and suggest misleading alternative diagnoses.
Subject(s)
Bone Neoplasms/diagnosis , Bone Neoplasms/secondary , Osteitis Deformans/diagnosis , Osteosarcoma/diagnosis , Prostatic Neoplasms/pathology , Sarcoma/diagnosis , Aged , Aged, 80 and over , Diagnosis, Differential , Femur/diagnostic imaging , Humans , Humerus/diagnostic imaging , Male , Radiography , Radionuclide Imaging , Tibia/diagnostic imagingABSTRACT
The status of mitochondrial functioning in Reye's syndrome was assessed by comparing organic acid profiles from nine pathological urines with those from normal urines. It was found that Reye's syndrome urines have a normal content of succinic, oxaloacetic, aconitic, and citric acids suggesting that the enzymes of the acid cycle are functional. Elevated pyruvate and depressed alpha-ketoglutarate levels were observed. Abnormal urinary constituents detected were salicylic and adipic acids. Presence of the latter indicates that the enzymes of fatty acid beta-oxidation are functional.
