Mapping of linear B-cell epitopes on viral polypeptides by multiple Peptide synthesis and fine tuning sensitivity and specificity of the identified Peptide antigens for application in virus diagnosis.

This chapter focuses on methods for epitope mapping on novel viral polypeptrdes and on fine tuning sensitivity and spectficity of the identified peptide antigens for application in virus diagnosis. Because of the development of efficient methods of multiple peptrde synthesis (1-3), antigenic sates of many proteins could be detected.