1.
Org Lett
; 24(1): 202-206, 2022 01 14.
Article
in English
| MEDLINE
| ID: mdl-34904840
ABSTRACT
The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed a bridgehead olefin and C-5/C-13 hydroxy groups in a one-step operation. The novel Ag-promoted oxetane formation smoothly constructed the tetracyclic framework of paclitaxel.
