ABSTRACT
Indications for RIST have not been established in patients with solid tumors. In this study, we performed RIST as immunotherapy in a 13-yr-old girl with intractable but not progressive osteosarcoma, which originated from the inter-costal region. Carcinomatous pleurisy suddenly developed after the start of a conditioning regimen that included Flu and BUS. She died of respiratory failure on day +19 without signs of engraftment. This case suggests that unexpected acceleration of tumor growth may occur following RIST with immunosuppressive drugs before the development of a beneficial GVT effect.
Subject(s)
Antineoplastic Agents/adverse effects , Bone Neoplasms/pathology , Immunosuppression Therapy/adverse effects , Osteosarcoma/secondary , Pleural Neoplasms/secondary , Vidarabine/analogs & derivatives , Antineoplastic Agents/therapeutic use , Bone Neoplasms/diagnosis , Bone Neoplasms/drug therapy , Child , Disease Progression , Fatal Outcome , Female , Humans , Magnetic Resonance Imaging , Myeloablative Agonists , Osteosarcoma/diagnosis , Osteosarcoma/drug therapy , Pleural Neoplasms/diagnosis , Radiography, Thoracic , Vidarabine/adverse effects , Vidarabine/therapeutic useABSTRACT
We report here the reconstitution after bone marrow transplantation (BMT) in identical infant twins with acute myelogenous leukemia (AML). They were diagnosed at 8 and 9 months of age. Complete remission was induced after two courses of chemotherapy. After four and five courses of chemotherapy, respectively, they received BMT at 2-month interval from the same HLA-identical older brother. The total dose of marrow nucleated cells (NC) harvested was 77.7 x 10(8). The first patient was transplanted with half of the total dose of NC. The remaining cells were cryopreserved without the use of a programmed freezer and transplanted into the second patient 2 months later. The number of days for neutrophil (>0.5 x 10(9)/L), platelet (>50 x 10(9)/L), and reticulocyte (>1%) recovery were, respectively, 15, 21, and 14 in the first case and 12, 21, and 15 in the second case. The clinical courses after BMT were uneventful in both cases, except for mild acute GVHD, and complete remission has been maintained >4 yr with full recovery of immune and marrow function. Based on the results in these cases, we confirmed that marrow cells that have been cryopreserved without the use of a programmed freezer could reconstitute immune and marrow function as well as non-cryopreserved cells.
Subject(s)
Bone Marrow Transplantation , Cryopreservation , Diseases in Twins/surgery , Leukemia, Myeloid, Acute/surgery , Child, Preschool , Humans , Infant , Living Donors , Male , Siblings , Time FactorsABSTRACT
An intra-abdominal mass was observed by fetal ultrasonography at 32 weeks of gestation. The baby was diagnosed as having neuroblastoma at the time of delivery at 39 weeks and its lower extremities were completely paralyzed. The chemotherapy after birth was quite effective to reduce the mass volume but neurological sequelae failed to improve. By carefully monitoring the movement of extremities, it may have been possible to prevent irreversible by inducing delivery before that state was reached.
Subject(s)
Neuroblastoma/complications , Neuroblastoma/diagnostic imaging , Paralysis/etiology , Ultrasonography, Prenatal , Antineoplastic Agents/therapeutic use , Female , Fetal Diseases/diagnostic imaging , Humans , Infant, Newborn , Lower Extremity/physiopathology , Nervous System Diseases , Neuroblastoma/drug therapy , Paralysis/embryology , Paralysis/prevention & control , Pregnancy , Spinal Cord Compression/embryology , Spinal Cord Compression/etiology , Spinal Cord Compression/prevention & controlABSTRACT
An 8-year-old girl with acute leukemia had bacteremia caused by Klebsiella pneumoniae producing CTX-M-2-type broad spectrum beta-lactamase. K. pneumoniae and Escherichia coli strains producing the same enzyme and harboring identical conjugative plasmids were recovered from stoor culture. Patients with frequent episodes of neutropenia and prophylactic administration of beta-lactams are at risk of harboring colonizing strains that produce broad spectrum beta-lactamases.
