1.
Org Biomol Chem
; 12(44): 8832-5, 2014 Nov 28.
Article
in English
| MEDLINE
| ID: mdl-25294088
ABSTRACT
The unusual sugars, α-aculosides, which appear in certain antibiotics and have an α,ß-unsaturated ketone structure, were found to be novel and selective Michael acceptors for the thiol function of cysteine residues. A coumarin derivative possessing α-aculoside as a Michael acceptor effectively and irreversibly operated as a fluorescent probe in cells. Furthermore, α-aculosides exhibited cytotoxic activity against several cancer cell lines.