[Effect of repeated immunization with inactivated influenza vaccine on the formation of specific and nonspecific immunity factors]. / Vliianie povtornoi immunizatsii inaktivirovannoi grippoznoi vaktsinoi na formirovanie spetsificheskikh i nespetsificheskikh faktorov immuniteta.

A group of young people, totaling 1160 persons, was immunized annually with influenza inactivated chromatographic divaccine prepared from influenza viruses A (H1N1 +/- H3N2) for 3 years. Only in persons immunized once or twice direct correlation between the number of immunizations and their immunological effectiveness was observed. Repeated immunization produced no stimulating effect on the level of systemic humoral and secretory immunity. The innocuity of repeated vaccinations is substantiated by the absence of such effect on the somatic morbidity of the vaccinees and the levels of complement, lysozyme and beta-lysin in the blood serum.