Subject(s)
Respiratory Tract Infections/drug therapy , Salicylates/adverse effects , Seizures/drug therapy , Valproic Acid/adverse effects , Virus Diseases/drug therapy , Acute Disease , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Respiratory Tract Infections/complications , Salicylates/therapeutic use , Seizures/complications , Valproic Acid/therapeutic use , Virus Diseases/complicationsABSTRACT
A possibility of construction of a mathematical model for current prognosing of aseptic meningitis incidence both for 2-4 months in advance and for the whole year has been demonstrated. The initial information consisted of the data on prevalence of enteroviruses in water objects as from May. Comparison of the actual and estimated incidence indicates that with the proposed model, up to 90.4% of the incidence of aseptic meningitis may be explained.
Subject(s)
Computer Simulation , Enterovirus Infections/epidemiology , Meningitis, Aseptic/epidemiology , Meningitis, Viral/epidemiology , Meningitis/epidemiology , Water Microbiology , Enterovirus Infections/etiology , Humans , Incidence , Meningitis, Aseptic/etiology , Meningitis, Viral/etiology , Prognosis , Regression Analysis , Time FactorsSubject(s)
Brain Injuries/blood , Prostaglandins/blood , Adolescent , Child , Child, Preschool , HumansSubject(s)
Communicable Diseases/complications , Nervous System Diseases/etiology , Toxemia/complications , Adolescent , Child, Preschool , Female , Humans , Infant , MaleSubject(s)
Brain Diseases/blood , Erythrocytes/metabolism , Hyperlipidemias/etiology , Lipids/blood , Child, Preschool , Cholesterol/blood , Fatty Acids/blood , Female , Glycerides/blood , Humans , Infant , Male , PhospholipidsABSTRACT
Lipids, lipoproteins and lipid peroxidation in the blood serum, erythrocyte membranes and CSF were examined in 110 patients (aged 1 month to 3 years) with infectious neurotoxicosis developed in the presence of acute respiratory viral infections, pneumonia and intestinal infection. The results obtained showed a considerable fall in the level of total phospholipids and in their individual fractions in the blood serum and erythrocyte membranes; and their elevation in the CSF as well as increased lipid peroxidation in the blood serum and in the CSF. Among the questions discussed is a possible involvement of upset metabolism of lipids and their peroxides in the pathogenesis of infectious-toxic impairments of the nervous system in children of early age. The questions of their correction with lipostabilizing agents are also reviewed.
Subject(s)
Central Nervous System Diseases/etiology , Intestinal Diseases/complications , Lipids/analysis , Lipoproteins/blood , Respiratory Tract Infections/complications , Virus Diseases/complications , Central Nervous System Diseases/metabolism , Child, Preschool , Erythrocyte Membrane/analysis , Female , Humans , Infant , Male , Membrane Lipids/blood , Pneumonia/complicationsABSTRACT
The authors present the results of examining the plasma lipids in 62 children with an infectious neurotoxic syndrome. The children were suffering from acute respiratory viral infections, lobular pneumonia, or intestinal infections. Hyperlipidemia and dysphospholipidemia were revealed: the former was due primarily to a rise of the content of non-saturated fatty acids and triglycerides, and the latter to a drop of the lecithin and cephaline levels. These changes correlated with the disease gravity. No substantial differences in the plasma lipid spectrum were revealed in the children with the neurotoxicoses due to the acute respiratory infections, pneumonias, and intestinal infections, however, in the latter cases a more marked rise of the triglyceride content was noted.
