ABSTRACT
The frequency of diagnostic titers of antibodies to Borrelia burgdorferi in 289 examinees suffering from neurological diseases made up 10.4%, while in the population this figure was under 1.9%. Lyme-borreliosis was detected in 11 (3.8%) patients, 2 of them had mixed infection with tick-borne viral encephalitis. In 10 patients (3.5%) the diagnosis of neuroborreliosis required verification with other techniques. It is thought valid to perform serological screening for neuroborreliosis only in patients with tick-born encephalitis to identify mixed infection.
Subject(s)
Antibodies, Bacterial/analysis , Borrelia burgdorferi Group/immunology , Encephalitis, Viral/epidemiology , Endemic Diseases , Lyme Disease/epidemiology , Lyme Disease/immunology , Adolescent , Adult , Aged , Child , Encephalitis, Viral/complications , Encephalitis, Viral/immunology , Female , Humans , Incidence , Lyme Disease/complications , Male , Middle Aged , Russia/epidemiology , Serologic TestsABSTRACT
Lyme borreliosis in the Sverdlovsk region was epidemiologically analysed on the basis of the patients' referral to the Center of Lyme Borreliosis. From 1991 to 1993 a total of 873 cases of specified Lyme borreliosis were recorded. The main epidemiological characteristics of Lyme borreliosis coincided with those of tick-borne viral encephalitis. The endemic areas virtually covered all the districts of the region with the foci concentrated around large cities in the south and south-west of the region. The risk of Lyme borreliosis was found to increase with the patient's age and the duration of tick's attachment. Rural and urban residents are at an equal risk of the disease.
Subject(s)
Lyme Disease/epidemiology , Adult , Age Distribution , Antibodies, Bacterial/blood , Borrelia burgdorferi Group/immunology , Female , Humans , Lyme Disease/immunology , Lyme Disease/transmission , Male , Middle Aged , Prevalence , Rural Population/statistics & numerical data , Seroepidemiologic Studies , Sex Distribution , Siberia/epidemiology , Urban Population/statistics & numerical dataABSTRACT
The effect of methylcobalamin on 3H-methotrexate uptake by tumor and normal tissues of mice with mammary adenocarcinoma (Ca-755) was studied. Methylcobalamin stimulated the rate of 3H-methotrexate influx into the tumor and small intestine but did not change its influx into the spleen. The effect was dependent on the dose of methylcobalamin. Comparative analysis of the kinetic differences in 3H-methotrexate influx and efflux in tumor and susceptible host tissues revealed the optimal dose of methylcobalamin 0.01 mg/kg to improve the antitumor drug action.
