Subject(s)
Internal Medicine , Military Medicine , Therapeutics , Warfare , History, 20th Century , USSRABSTRACT
Data on the study of the genetics of ischemic heart disease by means of the classical methods (genealogical, population-statistical, and twin) are discussed. The results of a follow-up, conducted for many years, of the condition of close relatives of sick and healthy probands, who were found to be practically healthy during the first examination are discussed. Clinical biochemical examination of the relatives of sick probands is considered a necessary stage in the further clinical study of the genetic factors in ischemic heart disease. The most important problems in the study of the genetics of ischemic heart disease in the clinic are outlined.
Subject(s)
Coronary Disease/genetics , Adult , Death, Sudden/epidemiology , Female , Genetic Techniques , Humans , Male , Middle Aged , Myocardial Infarction/genetics , Prospective Studies , Time FactorsABSTRACT
On the basis of the medical history and clinical examination of members of families of 133 practically healthy probands and probands suffering from ischemic heart disease and comparison of the frequency of this disease among: (1) husbands and wives and relatives of brother-sisters of probands with ischemic heart disease; (2) husbands and wives, living together for a long time, one of whom had a favourable heredity while the heredity of the other is aggravated by vascular and metabolic diseases; (3) step-borthers and step-sisters born of remarriage of a healthy person to another healthy person in one case and to a sick person in another; (4) persons related in different extent to a sick proband, the authors conclude that genetic factors are very important in the development of coronary atherosclerosis and ischemic heart disease.
Subject(s)
Coronary Disease/genetics , Adult , Coronary Disease/epidemiology , Female , Humans , Intracranial Arteriosclerosis/genetics , Male , Middle AgedABSTRACT
The content of 10 trace elements was studied by employing the neutron-activation method and the lead level determined through the spectral analysis in the whole blood, aorta, the heart muscle, liver, intesties (small and large), in the pancreas, adrenal glands, the spleen, lungs of accident victims, among whom 87 were practically healthy and 91 had atherosclerosis. The latter demonstrated in a number of organs (especially in the aorta and liver) a reduction in the content, which increased with age and intensity of atherosclerotic changes, of nickel, manganese, zinc, cobalt, vanadium and iron and rise in the lead, gallium, copper, bismuth and bromine level. The disclosed data bear witness to a definite part played by a number of trace elements in the atherogenesis.
