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Clin Pharmacol Ther ; 114(2): 262-265, 2023 08.
Article in English | MEDLINE | ID: mdl-37314952

ABSTRACT

Aminoglycoside antibiotic exposure can result in ototoxicity and irreversible hearing loss among individuals that harbor the m.1555A>G variant in the mitochondrial 12S rRNA gene, MT-RNR1. Importantly, pre-emptive m.1555A>G screening has been shown to reduce the prevalence of pediatric aminoglycoside-induced ototoxicity; however, professional guidelines to support and guide post-test pharmacogenomic counseling in this context are not currently available. This Perspective highlights key issues with delivering MT-RNR1 results, including longitudinal familial care considerations and communicating m.1555A>G heteroplasmy.


Subject(s)
Aminoglycosides , Genes, rRNA , Ototoxicity , Child , Humans , Aminoglycosides/adverse effects , Anti-Bacterial Agents/adverse effects , DNA, Mitochondrial/genetics , Mutation , Ototoxicity/genetics , Pharmacogenetics
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