ABSTRACT
Two drugs in the form of coated tablets: Promazin (promazine hydrochloride) (1) and Thioridazin (thioridazine hydrochloride) (2), and tablets Clotrimazolum (clotrimazole) (3) were assayed gravimetrically and spectrophotometrically in the same process using complexes with ammonium molybdate. Stoichiometry of these complexes was established by elemental analysis and analysis of the incineration residue (MoO3). The complexes were subsequently characterized using their IR and UV spectra and melting points. The active substances of the complexes were also determined spectrophotometrically. Using this method Beers Law was found to hold for the concentration ranges of 5-40 microg/ml (complex of 1), 5-60 (microg/ml (complex of 2) and 2-10 microg/ml (complex of 3). The method was validated in terms of precision, linearity, detection limit and quantification limit. The two methods of drug determination, used in a single analytical process verify each other.
Subject(s)
Imidazoles/analysis , Phenothiazines/analysis , Anti-Bacterial Agents/analysis , Enzyme Inhibitors/analysis , Enzyme Inhibitors/chemistry , Imidazoles/chemistry , Macrolides , Spectrophotometry, Ultraviolet/methods , Spectrophotometry, Ultraviolet/statistics & numerical data , Tablets , Tablets, Enteric-CoatedABSTRACT
Four drugs in the form of coated tablets: Amitryptylinum (Amitryptyline) (1), Imipramin (Imipramine) (2), Chloropyribenzaminum (Chloropyramine) (3), and Phenazolinum (Antazoline) (4) were determined gravimetrically and spectrophotometrically in the same process by using complexes with ammonium molybdate. Stoichiometry of the complexes was established by elemental analysis and analysis of the incineration residue (MoO3). The complexes were characterized by IR and UV spectra and melting points. Contents of the drugs in the complexes were also determined spectrophotometrically. In this method Beer's law was found to obey over the concentration ranges 10-80 micrograms/ml (complex of 1), 10-100 micrograms/ml (complexes of 2 and 3), and 10-60 micrograms/ml (complex of 4). This method was validated in terms of precision, linearity, limit of detection and limit of quantitation. The two methods of the drug determination used in a single process of analysis, verify each other.
Subject(s)
Amines/chemistry , Chemical Phenomena , Chemistry, Physical , Spectrophotometry, Ultraviolet , Tablets, Enteric-Coated/analysisABSTRACT
Suitability of four arylosulfonic acids and their sodium salts to form derivatives with hypotensive drugs were studied. New crystalline arylosulfonates of todralazine, hydralazine and dihydralazine were obtained. Physico-chemical properties of the obtained arylosulfonates were tested. Reagents mentioned above were also used in analysis of these drugs.
Subject(s)
Antihypertensive Agents/analysis , Dihydralazine/analysis , Hydralazine/analysis , Sulfonic Acids/analysis , Todralazine/analysisABSTRACT
Suitability of three phenylsulphonyloxybenzenesulfonic acids and their sodium salts to form new derivatives with antidepressive drugs were studied. Then physicochemical properties of the obtained arylosulfonates were tested. Reagents mentioned above were also used in analysis of these drugs.
Subject(s)
Antidepressive Agents/analysis , Arylsulfonates/analysis , Arylsulfonates/chemistry , Dihydralazine/analysis , Hydralazine/analysis , Indicators and Reagents , Todralazine/analysisABSTRACT
The new immunosuppressive and anti-inflammatory agents have been searched in a group of the synthetic L-cysteine and 3-acetyl-thiazolidine-4-carboxylic acid derivatives. Synthesis of 17 compounds is reported.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Cysteine/analogs & derivatives , Immunosuppressive Agents/chemical synthesis , Thiazoles/chemical synthesis , Cysteine/chemical synthesis , Cysteine/immunology , Thiazoles/immunologyABSTRACT
In continued search for new compounds with immunotropic and anti-inflammatory activity we developed synthesis of the seven following new derivatives of L-cysteine: S-methyl-N-acetylcysteine amide, hydrazide and acetylhydrazide, acetyl derivatives of S-methyl-N-acetylcysteine methylhydrazide, S-methylcysteine morpholineamide and S-methyl-N-acetylcysteine morpholineamide. In general the syntheses consisted in obtaining esters of cysteine and S-methylcysteine, which were submitted to aminolysis and the obtained derivatives were acetylated with acetic anhydride. S-Methylcysteine morpholineamides were obtained by condensation of morpholine with cysteine derivatives by carbodiimied and/or mixed anhydride method. Yields of the compounds were high. Elemental composition was confirmed by elementary analysis.
Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Cysteine/analogs & derivatives , Immunosuppressive Agents/chemical synthesis , Cysteine/chemical synthesis , Structure-Activity RelationshipABSTRACT
Working on the problem entitled "Synthesis of cysteine derivatives of immunotropic activity" the following compounds were synthesized; cysteine hydrazide and its hydrochloride, S-methylcysteine hydrazide hydrochloride, S, N, N-trimethylcysteine and S-benzylcysteinyl-S-benzylcysteine. We modified the synthesis of cysteine hydrazide and prepared its hydrochloride. This way a better yield and simplification of the synthesis were achieved. The above compounds were obtained with good yields.
