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Infect Immun ; 65(4): 1527-30, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9119498

ABSTRACT

The kdsA and kdsB genes from Chlamydia trachomatis encoding 3-deoxy-D-manno-octulosonate (KDO)-8-phosphate synthetase and CMP-KDO synthetase were identified by functional complementation of temperature-sensitive Salmonella typhimurium mutants, homology to known KDO-8-phosphate synthetase and CMP-KDO synthetase proteins, and in vitro enzyme activity. The kdsA gene was transcribed as part of a polycistronic mRNA with two downstream open reading frames (ORFs). One of these ORFs appeared to encode a membrane-anchored protein, while the second encoded a protein showing homology to the ATP-binding component of periplasmic binding protein-dependent ABC transporters. Transcription of kdsA and kdsB in C. trachomatis was evident within 4 h of initiation of the C. trachomatis infection process and continued throughout the chlamydial life cycle.


Subject(s)
Aldehyde-Lyases/genetics , Chlamydia trachomatis/genetics , Gene Expression Regulation, Bacterial , Gene Expression Regulation, Developmental , Nucleotidyltransferases/genetics , Amino Acid Sequence , Base Sequence , Chlamydia trachomatis/enzymology , Chlamydia trachomatis/growth & development , Molecular Sequence Data , Sequence Alignment
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