ABSTRACT
Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Histology confirmed pyoderma gangrenosum.
Le Pyoderma gangrenosum (PG) est une affection rare appartenant au groupe des dermatoses neutrophiliques. Cette entité est associée à l'existence de maladies systémiques et autoimmunes, mais exceptionnellement à une hépatite auto-immune. Nous rapportons l'observation d'une patiente âgée de 40 ans atteinte d'une hépatite auto-immune (HAI) de type 1 depuis 12 ans admise pour une lésion ulcéreuse du membre inférieur gauche. L'histologie confirmera l'existence d'un pyoderma gangrenosum.
ABSTRACT
Pseudopheochromocytoma has a clinical presentation that is similar to pheochromocytoma. It manifests itself with paroxysmal hypertension crises, associated with various symptoms such as headaches, chest pain, nausea, palpitations, and dizziness. Patients are usually asymptomatic in between the crises. Unlike pheochromocytoma, there is no catecholamines overproduction in this pathology: hypertensive peaks are caused by a hyperactivation of the sympathetic nervous system, which is often triggered by a psychological trauma in the past. Treatment of pseudopheochromocytoma can be challenging due to normal blood pressure values in between the hypertensive peaks; it includes alpha- and beta-blockers for moderate crises and prevention and must be combined with psychopharmacologic agents such as anxiolytics or antidepressant drugs. Psychotherapy and dietetic treatment are also crucial in pseudopheochromocytoma management.
ABSTRACT
Hypertrophic osteoarthropathy is sometimes the paraneoplasic manifestation of cancer of pulmonary origin. It is rarely present in case of breast cancer, even at a metastatic stage. In its complete form, this entity includes periostitis (predominantly bilateral and affecting upper and lower limbs), digital clubbing and, rarely, arthritis. We report the case of a female patient with metastatic breast cancer and an incomplete form of hypertrophic osteoarthropathy, clearly asymetric and without digital clubbing.
Subject(s)
Bone Neoplasms/complications , Bone Neoplasms/secondary , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/secondary , Osteoarthropathy, Secondary Hypertrophic/etiology , Aged , Female , HumansABSTRACT
UNLABELLED: Our study aims to identify correlations between the metabolic syndrome and cardiovascular diseases determinism. MATERIAL AND METHODS: A retrospective study was carried out on a sample of 1463 patients of which 734 patients met the diagnostic criteria of cardiometabolic syndrome, admitted in the Clinic of Cardiovascular Rehabilitation, Rehabilitation Hospital, Iasi, between 01.01.2009-31.12.2009. RESULTS: The incidence of cardiometabolic syndrome has a soft predominance on the group 40-59 years (61.66%). The high level of hypertension was found in the patients group 48-69 years (53.70%) and lowest in the patients group 25-38 years (11.35%) (p = 0.001). The coronary heart diseases showed a significant difference between age groups: 48-69 years (41.80%), compared to 25-38 years (7.55%) (p = 0.003). Heart failure is part of the same age distribution curve (45%, 6.8%) (p = 0.02). CONCLUSIONS: The metabolic syndrome is a predictor of the occurrence and development cardiovascular disease.
