ABSTRACT
Comparative analysis of the pharmacokinetics and bioequivalence of a new dipeptide anxiolytic compound GB-115 in three drug forms for peroral administration, developed in the experimental technology department of the Institute of pharmacology RAMS, was carried out. Three drug forms of GB-115 and a micronized substance of this compound were different in composition and technology of production. As a result of the investigations of GB-115 pharmacokinetics, drug form No. 2 (with a relative bioequivalence of 192%) showed advantages in comparison to the micronized parent substance and two other drug forms (bioequivalence, 53 and 117%) and can be recommended for further pharmacological studies.
Subject(s)
Anti-Anxiety Agents/pharmacokinetics , Dipeptides/pharmacokinetics , Animals , Anti-Anxiety Agents/pharmacology , Biological Availability , Dipeptides/pharmacology , Male , RatsABSTRACT
Afobazole pharmacokinetics upon oral administration of tablets prepared according to various technologies was studied in rabbits. The main pharmacokinetic parameters were determined.
Subject(s)
Anti-Anxiety Agents/pharmacokinetics , Benzimidazoles/pharmacokinetics , Morpholines/pharmacokinetics , Animals , Anti-Anxiety Agents/pharmacology , Benzimidazoles/pharmacology , Delayed-Action Preparations/pharmacokinetics , Delayed-Action Preparations/pharmacology , Male , Morpholines/pharmacology , RabbitsABSTRACT
We have recently introduced a quantum mechanical polarizable force field (QMPFF) fitted solely to high-level quantum mechanical data for simulations of biomolecular systems. Here, we present an improved form of the force field, QMPFF2, and apply it to simulations of liquid water. The results of the simulations show excellent agreement with a variety of experimental thermodynamic and structural data, as good or better than that provided by specialized water potentials. In particular, QMPFF2 is the only ab initio force field to accurately reproduce the anomalous temperature dependence of water density to our knowledge. The ability of the same force field to successfully simulate the properties of both organic molecules and water suggests it will be useful for simulations of proteins and protein-ligand interactions in the aqueous environment.
