[The effect of various organochlorine pesticides on the immunologic reactivity of the white rat]. / Beitrag zum Einfluss einiger organochlorurierter Pestizide auf die immunologische Reaktivität der weissen Ratte.

Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.

[Effects of Entomoxan on various lymphatic organs of the chicken]. / Auswirkungen von Entomoxan auf einige Lymphorgane des Huhnes

The effect of an organochlorine compound (Entomoxan) on the bursa of Fabricius and the thymus was followed in chicks given a ration containing 15 ppm daily for 8 weeks, starting at 3 weeks of age. Birds were killed 2,4,6 or 8 weeks after the start of treatment. Total protein, RNA, DNA, nitrogen, free amino acids and water content were determined in both lymphatic organs. Two weeks of treatment with Entomoxan produced a stress-like effect, with loss of weight of both organs and important biochemical changes. Such changes were still present after 4 weeks, although there was no longer any difference in organ weight in comparison with the controls. After six weeks of treatment the changes in the bursa were slight and there were no changes in the thymus. Some changes were still present at the 8th week, but ther was no indication of a stress effect.