1.
Bioorg Med Chem Lett
; 11(13): 1671-3, 2001 Jul 09.
Article
in English
| MEDLINE
| ID: mdl-11425534
ABSTRACT
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
Subject(s)
Aminophenols/chemistry , Antineoplastic Agents/pharmacology , Mitosis/drug effects , Sulfonamides/chemistry , Sulfonic Acids/pharmacology , Antineoplastic Agents/chemistry , Humans , Sulfonic Acids/chemistry , Tumor Cells, Cultured
2.
Bioorg Med Chem Lett
; 11(7): 871-4, 2001 Apr 09.
Article
in English
| MEDLINE
| ID: mdl-11294380
ABSTRACT
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
