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J Nat Med ; 70(3): 384-90, 2016 Jul.
Article in English | MEDLINE | ID: mdl-26936787

ABSTRACT

The methanolic extract of Lawsonia inermis L. (henna) showed accelerative effects on nerve growth factor-induced neurite outgrowth in PC12 cells under non-fasting conditions. To elucidate the active constituents responsible for the neuronal differentiation, we conducted a search of the constituents and examined their accelerative effects on neurite outgrowth in PC12 cells. We isolated a new acetophenone glycoside, inermioside A, which exerted a significant accelerative effect on neurite outgrowth. We also confirmed the activities of nine known compounds, including quercetin and lalioside. In addition, we found that quercetin, one of the active constituents, increased Vav3 mRNA expression.


Subject(s)
Flowers/chemistry , Lawsonia Plant/chemistry , Neuronal Outgrowth/physiology , Plant Extracts/chemistry , Animals , PC12 Cells , Rats
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