ABSTRACT
OBJECTIVE: To examine the characteristics of patients who developed late onset systemic lupus erythematosus (SLE) in the GLADEL (Grupo Latino Americano de Estudio del Lupus) cohort of patients with SLE. METHODS: Patients with SLE of less than two years of disease duration, seen at 34 centers of nine Latin American countries, were included. Late-onset was defined as >50 years of age at time of first SLE-related symptom. Clinical and laboratory manifestations, activity index (SLEDAI), and damage index (SLICC/ACR- DI) were ascertained at time of entry and during the course (cumulative incidence). Features were compared between the two patient groups (<50 and ≥50) using descriptive statistics and hypothesis tests. Logistic regression was performed to examine the association of late-onset lupus, adjusting for other variables. RESULTS: Of the 1480 patients included, 102 patients (6.9 %) had late-onset SLE, 87% of which were female. Patients with late-onset SLE had a shorter follow-up (3.6 vs. 4.4 years, p < 0.002) and a longer time to diagnosis (10.1 vs. 5.8 months, p < 0.001) compared to the younger onset group. Malar rash, photosensitivity, and renal involvement were less prevalent while interstitial lung disease, pleural effusions, and sicca symptoms were more frequent in the older age group (p > 0.05). In multivariable analysis, late onset was independently associated with higher odds of ocular (OR = 3.66, 95% CI = 2.15-6.23), pulmonary (OR = 2.04, 95% CI = 1.01-4.11), and cardiovascular (OR = 1.76, 95% CI = 1.04-2.98) involvement and lower odds of cutaneous involvement (OR = 0.41, 95% CI = 0.21-0.80), number of cumulative SLE criteria (OR = 0.79, 95% CI = 0.64-0.97), use of cyclophosphamide (OR = 0.47, 95% CI = 0.24-0.95), and anti-RNP antibodies (OR = 0.43, 95% CI = 0.20-0.91). A Cox regression model revealed a higher risk of dying in older onset than the younger-onset SLE (OR = 2.61, 95% CI = 1.2-5.6). CONCLUSION: Late-onset SLE in Latin Americans had a distinct disease expression compared to the younger-onset group. The disease seems to be mild with lower cumulative SLE criteria, reduced renal/mucocutaneous involvements, and less use of cyclophosphamide. Nevertheless, these patients have a higher risk of death and of ocular, pulmonary, and cardiovascular involvements.
Subject(s)
Cyclophosphamide/therapeutic use , Immunosuppressive Agents/therapeutic use , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy , Lupus Erythematosus, Systemic/ethnology , Adolescent , Adult , Age of Onset , Aged , Female , Hispanic or Latino , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Severity of Illness Index , Young AdultABSTRACT
Chlorpheniramine maleate (CLOR) enantiomers were quantified by ultraviolet spectroscopy and partial least squares regression. The CLOR enantiomers were prepared as inclusion complexes with beta-cyclodextrin and 1-butanol with mole fractions in the range from 50 to 100%. For the multivariate calibration the outliers were detected and excluded and variable selection was performed by interval partial least squares and a genetic algorithm. Figures of merit showed results for accuracy of 3.63 and 2.83% (S)-CLOR for root mean square errors of calibration and prediction, respectively. The ellipse confidence region included the point for the intercept and the slope of 1 and 0, respectively. Precision and analytical sensitivity were 0.57 and 0.50% (S)-CLOR, respectively. The sensitivity, selectivity, adjustment, and signal-to-noise ratio were also determined. The model was validated by a paired t test with the results obtained by high-performance liquid chromatography proposed by the European pharmacopoeia and circular dichroism spectroscopy. The results showed there was no significant difference between the methods at the 95% confidence level, indicating that the proposed method can be used as an alternative to standard procedures for chiral analysis.
Subject(s)
1-Butanol/metabolism , Chlorpheniramine/analysis , Chlorpheniramine/chemistry , Spectrophotometry, Ultraviolet , beta-Cyclodextrins/metabolism , Calibration , Chlorpheniramine/metabolism , Chromatography, High Pressure Liquid , Circular Dichroism , StereoisomerismABSTRACT
The 1H and 13C NMR spectra of methyl (-)-zanzibarate (1), an ent-labdanic diterpene isolated from the epicarp of Hymenaea courbaril var. altissima (Leguminosaea, Cesalpinoideae, Detariae), was fully assigned by COSY experiments, 13C/1H shift correlation diagrams and NOE experiments.
Subject(s)
Aloe/metabolism , Chromones/analysis , Chromones/standards , Diterpenes/analysis , Diterpenes/chemistry , Fabaceae/metabolism , Magnetic Resonance Spectroscopy/methods , Magnetic Resonance Spectroscopy/standards , Brazil , Carbon Isotopes , China , Chromones/chemistry , Fruit/metabolism , Models, Molecular , Plant Extracts/analysis , Plant Extracts/chemistry , Plant Extracts/standards , Protons , Reference StandardsABSTRACT
Three known and two new diterpenes were isolated from the ethyl acetate extract of Hymenaea courbaril var. stilbocarpa seed pods. One of the compounds was elucidated as (5R*,8S*,9S*,10R*)-cleroda-3,13E-dien-15-oic acid and the other was elucidated, after treatment with diazomethane, as methyl (5S*,8S*,9S*,10R*)-cleroda-3,13E-dien-15-oate. The known diterpenes were identified as (-)-ozic acid, (-)-isoozic acid and (-)-kovalenic acid which were characterized as their methyl ester derivatives.
Subject(s)
Diterpenes, Clerodane , Diterpenes/chemistry , Fabaceae/chemistry , Seeds/chemistry , Diterpenes/isolation & purificationABSTRACT
Reduction of the alpha, beta-unsaturated ester moiety of (+)-methyl hardwickiate with magnesium in methanol afforded methyl (4aS,6S,8aS,1R,5R)-5, 6,8a-trimethyl-5-[2'-(3"-oxoyl)-ethyl-perhydro-1-naphthalenyl]- carboxaylate, while reduction with sodium in n-propanol, followed by esterification with diazomethane, furnished its C-4 epimer. After comparison of the 1H- and 13C-NMR data of these compounds with those reported for crolechinic acid isolated from Croton lechleri, a stereochemical revision for the natural product is suggested.
Subject(s)
Diterpenes/chemistry , Diterpenes/chemical synthesis , Magnesium/chemistry , Magnetic Resonance Spectroscopy , StereoisomerismABSTRACT
Syntheses of three enantiomers of natural hydroxybutenolide diterpenes, 16,18-dihydroxycleroda-3,13Z-dien-16,15-olide (4), (+)-16-hydroxycleroda-3,13Z-dien-16,15-olide (5), and (-)-16-hydroxyhalima-5(10),13Z-dien-16,15-olide (6), via a furan photosensitized oxygenation reaction of (+)-hardwickiic acid (2), are described.
Subject(s)
Diterpenes/chemistry , Diterpenes/chemical synthesis , Molecular Structure , Plants, Medicinal/chemistry , Spectrum AnalysisABSTRACT
OBJECTIVE: To evaluate the efficacy and tolerability of Parlodel LAR (Sandoz, Basel, Switzerland), a long-acting injectable bromocriptine, in PRL-secreting macroadenomas. DESIGN: Eleven patients with macroprolactinomas were studied in an academic environment in an open and prospective protocol. Ten patients were followed for 6 months and 8 for 1 year. Fifty to 200 mg IM of Parlodel LAR were administered every 28 days. RESULTS: At the end of the 1st month, 64% of the patients had PRL suppression of > 75% of baseline values. After 1 year, 88% of the cases had PRL suppression of > 90%. Persistent PRL normalization was seen in three cases. Tumor shrinkage was seen in 64% of the patients on day 5, in 73% on day 28, and in 90% after 6 months of treatment. Early visual field improvement was seen in 83% of the cases. All patients had improvement of clinical symptoms. CONCLUSION: Parlodel LAR is well tolerated and very effective in the long-term treatment of patients with PRL-secreting macroadenomas.
Subject(s)
Adenoma/drug therapy , Bromocriptine/therapeutic use , Pituitary Neoplasms/drug therapy , Prolactin/metabolism , Prolactinoma/drug therapy , Adenoma/blood , Adenoma/pathology , Adenoma/physiopathology , Adolescent , Adult , Analysis of Variance , Bromocriptine/administration & dosage , Bromocriptine/adverse effects , Delayed-Action Preparations , Female , Humans , Injections , Male , Middle Aged , Pituitary Neoplasms/blood , Pituitary Neoplasms/pathology , Pituitary Neoplasms/physiopathology , Prolactin/blood , Prolactinoma/blood , Prolactinoma/pathology , Prolactinoma/physiopathology , Prospective Studies , Visual FieldsABSTRACT
We describe a man in whom pyomyositis developed in a temperate climate. Three facts make this case unique. First the pyomyositis developed in someone with underlying dermatomyositis, this being the second reported case to our knowledge. Second, the organism involved was a Streptococcus and not a Staphylococcus as in most cases described, and the course of the disease was acute and not subacute as is usually reported. Finally, contrary to most described cases, surgical drainage was not necessary, probably because of the early diagnosis. Pyomyositis should be considered a possible cause of localized pain in patients with underlying inflammatory muscle disease.
Subject(s)
Climate , Dermatomyositis/complications , Myositis/complications , Myositis/microbiology , Streptococcal Infections/complications , Adult , Argentina/epidemiology , Dermatomyositis/diagnosis , Dermatomyositis/epidemiology , Humans , Male , Muscles/microbiology , Myositis/diagnosis , Streptococcal Infections/diagnosis , Streptococcal Infections/epidemiology , Streptococcus/isolation & purificationSubject(s)
Polymyalgia Rheumatica/drug therapy , Prednisolone/administration & dosage , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Middle Aged , RecurrenceSubject(s)
Retinitis Pigmentosa/etiology , Toxoplasmosis, Ocular/complications , Adult , Family Health , Female , Humans , Male , Middle Aged , PedigreeABSTRACT
diagnosticou-se papilopatia Diabetica em uma paciente jovem com sua diabetes regularmente controlada num exame oftalmologico de rotina.Sao discutidos o diagnostico, os diagnosticos diferenciais e a conduta. Foi feito um estudo evolutivo atraves de angiofluoresceinografia e campos visuais. O quadro final mostrou discreta palidez de papila unilateral com manutencao de funcao visual normal