1.
Org Lett
; 2(15): 2253-6, 2000 Jul 27.
Article
in English
| MEDLINE
| ID: mdl-10930256
ABSTRACT
Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.