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1.
Rev Med Interne ; 42(12): 875-880, 2021 Dec.
Article in French | MEDLINE | ID: mdl-34215457

ABSTRACT

INTRODUCTION: Cat scratch disease caused by Bartonella henselae with bone involvement is a rare presentation. CASE REPORT: We report a case of disseminated bartonellosis with multifocal osteomyelitis and multiple visceral involvement in an immunocompetent adult. Diagnostic confirmation was obtained by PCR on lymphadenopathy. In addition to our observation, 31 cases of bartonellosis with bone involvement were reported in the literature. Diagnosis is based on a combination of history, serology and PCR performed on tissue. The antibiotic treatment allows recovery in all cases. CONCLUSION: Cat scratch disease in its systemic form with bone involvement is a rare and difficult diagnosis for the clinician and an invasive approach is often required to obtain the diagnosis.


Subject(s)
Bartonella henselae , Cat-Scratch Disease , Osteomyelitis , Anti-Bacterial Agents/therapeutic use , Cat-Scratch Disease/complications , Cat-Scratch Disease/diagnosis , Humans , Osteomyelitis/diagnosis , Polymerase Chain Reaction
3.
Med Mal Infect ; 48(8): 516-525, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30401464

ABSTRACT

OBJECTIVES: To describe the epidemiological, clinical, microbiological, and therapeutic characteristics of Nocardiosis patients treated in a general hospital. PATIENTS AND METHODS: Monocentric retrospective analysis of patients presenting with Nocardia-positive biological sample from January 1, 1998 to May 1, 2017. RESULTS: We identified nine cases of Nocardia infections. Risk factors were oral corticosteroid therapy (n=3), solid cancer (n=2), hematological cancer (n=1), COPD (n=1). No risk factor was identified in patients with isolated cutaneous presentation (n=2). Disseminated presentations (n=3) were observed in patients receiving corticosteroid therapy (n=2) and presenting with ENT cancer (n=1). Identified Nocardia species were Nocardia nova (n=4), Nocardia cyriacigeorgica (n=2), Nocardia abscessus (n=1), Nocardia brasiliensis (n=1), and Nocardia asteroides (n=1). The median diagnostic time was 17 days. Antibiotic therapy was prolonged and included trimethoprim-sulfamethoxazole in 6/9 cases. The overall one-year case fatality was high (3/8). No recurrence was observed. We identified two cases of respiratory colonization with N. abscessus and N. cyriacigeorgica in COPD patients. CONCLUSION: Nocardiosis can occur both in immunocompetent and immunocompromised patients. It is a severe infection, with a miscellaneous clinical spectrum and complex treatments. Greater knowledge of nocardiosis is required from physicians for optimal medical care.


Subject(s)
Nocardia Infections , Aged , Aged, 80 and over , Female , Hospitalization , Hospitals, General , Humans , Male , Middle Aged , Nocardia Infections/diagnosis , Nocardia Infections/drug therapy , Nocardia Infections/epidemiology , Nocardia Infections/microbiology , Retrospective Studies , Time Factors
4.
Med Mal Infect ; 47(7): 453-458, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28943167

ABSTRACT

OBJECTIVE: To collect data of all patients admitted to hospital with a positive test to Bordetella bronchiseptica between 2001 and 2015. METHODS: We performed a retrospective monocentric study of all hospitalized patients over the past 15 years with a positive test to B. bronchiseptica. RESULTS: Nine patients were included between 2001 and 2015; two presented with infectious relapses, i.e. a total of 14 positive test samples were observed. Age, induced immunodeficiency, and preexisting respiratory illnesses are risk factors. All patients showed symptoms at sample collection and the infection was exclusively respiratory. The diagnosis was obtained through a cytobacteriological test of sputum, bronchial aspiration, or bronchial fibroscopy with a bronchoalveolar lavage. The drug susceptibility test revealed a natural resistance to cephalosporins including ceftazidime, monobactam, and fosfomycin. There were cases of resistance to penicillin A and to the trimethoprim/sulfamethoxazole association. The classically used antibiotic treatment for community-acquired pneumonia is based on probability and may thus fail. Four patients died. The duration and nature of the antibiotics to use have not been codified. CONCLUSION: B. bronchiseptica infection mainly affects the elderly. All patients should be treated, regardless of the importance of the inoculum, and all infected animals should be treated.


Subject(s)
Bordetella Infections/epidemiology , Bordetella/isolation & purification , Aged , Aged, 80 and over , Bordetella/drug effects , Bordetella Infections/diagnosis , Bordetella Infections/microbiology , Community-Acquired Infections/epidemiology , Community-Acquired Infections/microbiology , Cross Infection/epidemiology , Cross Infection/microbiology , Disease Susceptibility , Drug Resistance, Microbial , Female , Humans , Immunocompromised Host , Male , Middle Aged , Neoplasms/complications , Retrospective Studies , Risk Factors
5.
J Med Virol ; 83(3): 437-44, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21264864

ABSTRACT

New factors that influence the viral response in HCV non-genotype 2/3 patients must be identified in order to optimize anti-HCV treatment. This multicenter prospective study evaluates the influence of HCV variability and pharmacological parameters on the virological response of these patients to pegylated interferon α2a (peg-IFN-α2a: 180 µg/week) and ribavirin (RBV; 800-1,200 mg/day) for 48 weeks. HCV subtypes were identified by sequencing the NS5B region. Serum RBV and peg-IFN-α2a concentrations were measured at weeks 4 and 12. The 115 patients (67 men; median age = 49, range 31-76) included 64 who had never been treated and 27 co-infected with HIV. The mean baseline HCV RNA was 6.30 ± 0.06 log IU/ml and the HCV genotypes were: G1 (n = 93) with 1a (n = 37) and 1b (n = 50), G4 (n = 20) and G5 (n = 2). Most patients (79/108; 73%) had an early virological response. Independent predictors of an early virological response were interferon naive patients (OR= 2.98, 95% CI: 1.15-7.72) and RBV of >2,200 ng/ml at week 12 (OR = 3.41, 95% CI: 1.31-8.90). Forty of 104 patients (38%) had a sustained virological response. The only independent predictors of a sustained virological response were subtype 1b (OR = 6.82, 95% CI: 1.7-26.8), and HCV RNA <15 IU/ml at week 12 (OR = 25, 95% CI: 6.4-97.6). Thus a serum RBV concentration of >2,200 ng/ml was associated with an early virological response and patients infected with HCV subtype 1b had a better chance of a sustained virological response than did those infected with subtype 1a.


Subject(s)
Hepacivirus/drug effects , Hepacivirus/genetics , Hepatitis C, Chronic/drug therapy , Hepatitis C, Chronic/virology , Interferon-alpha/therapeutic use , Polyethylene Glycols/therapeutic use , Ribavirin/pharmacology , Ribavirin/therapeutic use , Adult , Aged , Antiviral Agents/blood , Antiviral Agents/therapeutic use , Drug Therapy, Combination , Female , Genotype , HIV Infections/complications , HIV Infections/virology , Humans , Interferon-alpha/blood , Male , Middle Aged , Prospective Studies , Recombinant Proteins/blood , Recombinant Proteins/therapeutic use , Ribavirin/blood , Treatment Outcome , Viral Load
6.
Rev Med Interne ; 26(4): 288-93, 2005 Apr.
Article in French | MEDLINE | ID: mdl-15820564

ABSTRACT

PURPOSE: To describe the clinical and radiographic features of patients with primary localized amyloidosis of the urinary tract. METHODS: We report a case of localized amyloidosis of the ureters and bladder. The medical records of four other cases from the French Register of localized amyloidosis were reviewed. RESULTS: The mean age of three men and two women was 53 years. All patients presented with gross hematuria, four patients presented with renal colic, only one patient had irritative lower urinary tract symptoms. Ureter and bladder were involved in three patients, both ureters in two patients and the bladder only, in one patient. Clinical and radiographic presentations mimicked a neoplasia excluded by histologic analysis. Immunohistochemical study was performed in only two cases and revealed lambda light chain amyloidosis. The median follow-up was eight years. Various treatments were performed, and recurrences occurred in two cases. None of the five patients developed monoclonal gammapathy or systemic amyloidosis. CONCLUSION: Primary localized amyloidosis of the urinary tract is a rare disorder and can easily be confused with a neoplasm. The physiopathology is unknown, the prognosis is usually good. There is no specific treatment, and repeated work-up for systemic amyloidosis is unnecessary as local recurrences appear to be the main complication.


Subject(s)
Amyloidosis/diagnosis , Ureteral Diseases/diagnosis , Urinary Bladder Diseases/diagnosis , Adult , Aged , Female , Humans , Male , Middle Aged
7.
Presse Med ; 31(24): 1131-3, 2002 Jul 13.
Article in French | MEDLINE | ID: mdl-12162098

ABSTRACT

INTRODUCTION: We report the case of severe colitis occurring during treatment with non-steroid anti-inflammatories (NSAI). OBSERVATION: A 57 year-old woman was hospitalized for lumbar pain that had not been relieved by AINS, tramadol and then morphine. The patient presented with septic shock and peritonitis by rectal perforation, followed by acute rectorrhagia. The endoscopic aspect evoked Crohn's disease with a recto-vaginal fistula. Progression was further complicated by two episodes of collapse because of acute rectorrhagia, requiring hemostasis colectomy and abdominal-perineal amputation. CONCLUSION: The diagnosis retained was AINS-induced colitis complicated by acute colectasia on a fecaloma with recto-vaginal fistula.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Colitis/chemically induced , Rectovaginal Fistula/etiology , Acute Disease , Colitis/complications , Female , Humans , Middle Aged , Severity of Illness Index
8.
Ann Med Interne (Paris) ; 152(4): 227-35, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11474369

ABSTRACT

We report a retrospective study of 115 hospitalized non-immunocompromised adults with proved or presumed diagnosis of cytomegalovirus infection. Clinical symptoms were fever (95%), constitutive symptoms (80%), joint and muscle pain (41%), shivering (32%), abdominal pain (26%), non-productive cough (20%), cutaneous eruption (20%), and diarrhea (10%). Examination found hepatomegaly (25%), splenomegaly (23%), cutaneous rash (20%), adenopathy (19%), pharyngitis (9%), jaundice (3%) or signs of meningeal irritation (1%). Seventeen patients had a gastrointestinal form (hepatitis, jaundice, colitis, antral gastritis or cholecystitis), eight had a pattern of hemopathy, two interstitial pneumonitis, two pericarditis, two immune thrombocytopenic purpura, two a polymyalgia rheumatica-like pattern, one thrombotic thrombocytopenic purpura, one cutaneous vasculitis and one meningoencephalitis. Sixty-four percent of the patients had atypical lymphocytosis. Hepatocellular injury occurred in 90% of the patients. Nineteen of the patients had biological immune abnormalities. Cytomegalovirus infection should be mainly suspected in any patient with persistent fever, isolated or associated with signs of poor specificity, or in some patients with visceral manifestations of initially unknown origin.


Subject(s)
Cytomegalovirus Infections/complications , Cytomegalovirus Infections/diagnosis , Immunocompetence , Adolescent , Adult , Aged , Aged, 80 and over , Blood Cell Count , Cough/virology , Cytomegalovirus Infections/blood , Cytomegalovirus Infections/immunology , Diarrhea/virology , Exanthema/virology , Fever/virology , Gastrointestinal Diseases/virology , Hepatomegaly/virology , Hospitalization/statistics & numerical data , Humans , Jaundice/virology , Lymphatic Diseases/virology , Meningitis/virology , Middle Aged , Pain/virology , Pericarditis/virology , Pharyngitis/virology , Retrospective Studies , Splenomegaly/virology , Thrombocytopenia/virology
9.
Rev Med Interne ; 21(7): 586-94, 2000 Jul.
Article in French | MEDLINE | ID: mdl-10942974

ABSTRACT

PURPOSE: Cytomegalovirus (CMV) infection in non-immunocompromised adults can sometimes induce hematological and immunological disorders that may mislead diagnosis. METHODS: Case reports of hospitalized non-immunocompromised adults with positive serology for CMV including the presence of immunoglobulin M or seroconversion were assessed in a retrospective study (1981-1998). We focused on clinical and biological abnormalities showing the role of CMV in disruption of functioning of hematological and immunological systems. RESULTS: Among 115 patients, lymphoma-like syndrome with large adenopathies and/or splenomegaly was diagnosed in eight patients, uncovering underlying CMV infection. Lymphoma was accompanied by hematoma in two patients. Three patients presented leg purpura (with thrombotic thrombocytopenic purpura in one case), one patient had cutaneous vasculitis and on other a Still's disease. Blood abnormalities were mononucleosis (64%), anemia (20%), and thrombopenia (25%) often of peripheral or hemolytic origin or due to hypersplenia. Electrophoresis of serum proteins showed an increase in immune globulins in 56% of the cases and monoclonal abnormality in nine cases. Immunological assessment was conducted in 18 patients. At least one abnormality was depicted in ten patients, consisting of either antinuclear, anti-platelet or anti smooth muscle antibodies, cryoglobulinemia, rheumatoid factor, or reduced complement fixation. CONCLUSION: Testing for CMV infection can be of value in case of blood or immunological disorders associated with clinical or biological signs. Although hematological disorders occur early, they are rarely severe. Immunological disorders are rarely symptomatic, but often raise issues regarding the potential genesis of immune diseases in at-risk patients.


Subject(s)
Cytomegalovirus Infections/blood , Cytomegalovirus Infections/immunology , Inpatients , Adolescent , Adult , Aged , Anemia/diagnosis , Cytomegalovirus/isolation & purification , Cytomegalovirus Infections/diagnosis , Diagnosis, Differential , Female , Humans , Immunoglobulin M/blood , Infectious Mononucleosis/diagnosis , Male , Middle Aged , Purpura, Thrombotic Thrombocytopenic/diagnosis , Skin Diseases/diagnosis , Still's Disease, Adult-Onset/diagnosis , Thrombocytopenia/diagnosis , Vasculitis/diagnosis
16.
Sem Hop ; 60(8): 534-7, 1984 Feb 16.
Article in French | MEDLINE | ID: mdl-6322335

ABSTRACT

The authors report 2 cases of autoimmune hemolytic anemia (AHA) and Hodgkin disease. The Hodgkin disease often precedes AHA. Most patients are found to have extensive disease; histologic features are classified as being of high grades of malignancy (mixed cellularity and nodular sclerosis types). Anti I, Rh, IgG auto antibody is commonly observed at 37 degrees C. AHA and Hodgkin disease are equally improved by chemotherapy. The prognosis and significance of this pathological association are unclear.


Subject(s)
Anemia, Hemolytic, Autoimmune/etiology , Hodgkin Disease/complications , Adult , Anemia, Hemolytic, Autoimmune/therapy , Autoantibodies/biosynthesis , Erythrocytes/immunology , Female , Hodgkin Disease/immunology , Hodgkin Disease/therapy , Humans , I Blood-Group System/immunology , Immunoglobulin G/biosynthesis , Male , Prognosis , Rh-Hr Blood-Group System/immunology
17.
Sem Hop ; 59(26): 1977-80, 1983 Jun 30.
Article in French | MEDLINE | ID: mdl-6310790

ABSTRACT

Twenty-nine patients, aged 19 to 87, were treated for an infection of the lower respiratory tract (pneumonia, bronchopneumonia, bronchitis, pulmonary abscess, pleuritis) due to a pathogen with in vitro sensitivity to the antibiotic (pneumococcus, hemophilus, anaerobic organisms . . .). Patients were given Moxalactam as the only antibacterial treatment. In most instances, excellent results (24 successes, i.e. 84% of cases) were recorded with two daily intramuscular injections of 1 g each. Biologic tolerance was satisfactory. Possible clinical side-effects are rashes and local pain during the injection. We conclude that Moxalactam is very effective in severe lower respiratory tract infections, with a daily dosage of 30 mg/kg.


Subject(s)
Bacterial Infections/drug therapy , Cephalosporins/therapeutic use , Cephamycins/therapeutic use , Respiratory Tract Infections/drug therapy , Adolescent , Adult , Aged , Bronchitis/drug therapy , Bronchopneumonia/drug therapy , Cephamycins/administration & dosage , Cephamycins/adverse effects , Female , France , Humans , Injections, Intramuscular , Male , Middle Aged , Moxalactam , Pneumonia/drug therapy
18.
Sem Hop ; 59(21): 1585-9, 1983 May 26.
Article in French | MEDLINE | ID: mdl-6310769

ABSTRACT

Case records of 37 patients with tuberculosis were analysed, out of 4 000 patients admitted to our department of internal medicine over a period of four years. The most common localisations are still pulmonary, but these are often atypical. Lymph node involvement is found in immigrants. More exceptional localisations (liver . . .) are reported. Tuberculosis has not yet become obsolete.


Subject(s)
Tuberculosis/diagnosis , Female , France , Humans , Male , Middle Aged , Tuberculin Test , Tuberculosis/epidemiology , Tuberculosis, Lymph Node/diagnosis , Tuberculosis, Meningeal/diagnosis , Tuberculosis, Miliary/diagnosis , Tuberculosis, Osteoarticular/diagnosis , Tuberculosis, Pulmonary/diagnosis
20.
Sem Hop ; 58(19): 1151-4, 1982 May 13.
Article in French | MEDLINE | ID: mdl-6285495

ABSTRACT

Two new observations of ISADH following head injury are described. A review of the medical literature is presented. Reports of ISADH after head injury are rare in comparison to the frequent occurrence of hydroelectrolytic disorders in the same situation. Attention is drawn to misleading clinical pictures, suggestive of neurosurgical conditions. Intracranial hematoma is frequently associated with ISADH and should be looked for in patients who fail to respond to therapy.


Subject(s)
Craniocerebral Trauma/complications , Inappropriate ADH Syndrome/etiology , Aged , Demeclocycline/therapeutic use , Female , Humans , Hyponatremia/etiology , Inappropriate ADH Syndrome/therapy , Male
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